Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Malcolm R. Ogborn; John F.S. Crocker; Paul C. Grimm

doi:10.1007/BF00858540

Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Malcolm R. Ogborn, John F.S. Crocker, Paul C. Grimm

Medicine

Medicine

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4 Citations (Scopus)

Abstract

We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

Original language	English
Pages (from-to)	314-316
Number of pages	3
Journal	Pediatric Nephrology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1007/BF00858540
Publication status	Published - Sept 1989

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Nephrology

PubMed: MeSH publication types

Case Reports
Journal Article

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10.1007/BF00858540

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abstract = "We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.",

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year = "1989",

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AU - Crocker, John F.S.

AU - Grimm, Paul C.

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N2 - We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

AB - We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

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Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Abstract

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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