Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Malcolm R. Ogborn; John F.S. Crocker; Paul C. Grimm

doi:10.1007/BF00858540

Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Malcolm R. Ogborn, John F.S. Crocker, Paul C. Grimm

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

4 Citations (Scopus)

Résumé

We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

Langue d'origine	English
Pages (de-à)	314-316
Nombre de pages	3
Journal	Pediatric Nephrology
Volume	3
Numéro de publication	3
DOI	https://doi.org/10.1007/BF00858540
Statut de publication	Published - sept. 1989

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Nephrology

PubMed: MeSH publication types

Case Reports
Journal Article

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10.1007/BF00858540

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abstract = "We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.",

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year = "1989",

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AU - Crocker, John F.S.

AU - Grimm, Paul C.

PY - 1989/9

Y1 - 1989/9

N2 - We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

AB - We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

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Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

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