Non-random occurrence of 7-14 translocations in human lymphocyte cultures

J. P. Welch; C. L.Y. Lee

doi:10.1038/255241a0

Non-random occurrence of 7-14 translocations in human lymphocyte cultures

J. P. Welch, C. L.Y. Lee

Medicine

Medicine

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Abstract

SOMATIC cells dividing in vitro occasionally show chromosome recombination between non-homologues most often in situations associated with an increased frequency of chromosome breakage and reunion^1,2 their occurrence being recognised by the observation of exchange figures. With the advent of new techniques for chromosome identification³ it is now possible to identify the chromosomes involved in these rearrangements and to recognise some translocations which might otherwise be missed.

Original language	English
Pages (from-to)	241-242
Number of pages	2
Journal	Nature
Volume	255
Issue number	5505
DOIs	https://doi.org/10.1038/255241a0
Publication status	Published - 1975

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Journal Article
Research Support, U.S. Gov't, P.H.S.

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10.1038/255241a0

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title = "Non-random occurrence of 7-14 translocations in human lymphocyte cultures",

abstract = "SOMATIC cells dividing in vitro occasionally show chromosome recombination between non-homologues most often in situations associated with an increased frequency of chromosome breakage and reunion1,2 their occurrence being recognised by the observation of exchange figures. With the advent of new techniques for chromosome identification3 it is now possible to identify the chromosomes involved in these rearrangements and to recognise some translocations which might otherwise be missed.",

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AU - Welch, J. P.

AU - Lee, C. L.Y.

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N2 - SOMATIC cells dividing in vitro occasionally show chromosome recombination between non-homologues most often in situations associated with an increased frequency of chromosome breakage and reunion1,2 their occurrence being recognised by the observation of exchange figures. With the advent of new techniques for chromosome identification3 it is now possible to identify the chromosomes involved in these rearrangements and to recognise some translocations which might otherwise be missed.

AB - SOMATIC cells dividing in vitro occasionally show chromosome recombination between non-homologues most often in situations associated with an increased frequency of chromosome breakage and reunion1,2 their occurrence being recognised by the observation of exchange figures. With the advent of new techniques for chromosome identification3 it is now possible to identify the chromosomes involved in these rearrangements and to recognise some translocations which might otherwise be missed.

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Non-random occurrence of 7-14 translocations in human lymphocyte cultures

Abstract

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