Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival

Mark Charman, Terry R. Colbourne, Antonietta Pietrangelo, Laurent Kreplak, Neale D. Ridgway

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

Background: The function of oxysterol-binding protein-related protein (ORP4) is unknown. Results: Silencing ORP4L or all ORP4 isoforms triggers growth arrest and apoptosis, which is suppressed by H-Ras and involves the C-terminal lipid binding domain. Conclusion: ORP4 is a sterol and PI-4P-binding protein required for survival and proliferation of immortalized and transformed cells. Significance: This is the first study to identify a mammalian ORP with growth regulatory activity.

Original languageEnglish
Pages (from-to)15705-15717
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
Publication statusPublished - May 30 2014

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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