TY - JOUR
T1 - Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival
AU - Charman, Mark
AU - Colbourne, Terry R.
AU - Pietrangelo, Antonietta
AU - Kreplak, Laurent
AU - Ridgway, Neale D.
PY - 2014/5/30
Y1 - 2014/5/30
N2 - Background: The function of oxysterol-binding protein-related protein (ORP4) is unknown. Results: Silencing ORP4L or all ORP4 isoforms triggers growth arrest and apoptosis, which is suppressed by H-Ras and involves the C-terminal lipid binding domain. Conclusion: ORP4 is a sterol and PI-4P-binding protein required for survival and proliferation of immortalized and transformed cells. Significance: This is the first study to identify a mammalian ORP with growth regulatory activity.
AB - Background: The function of oxysterol-binding protein-related protein (ORP4) is unknown. Results: Silencing ORP4L or all ORP4 isoforms triggers growth arrest and apoptosis, which is suppressed by H-Ras and involves the C-terminal lipid binding domain. Conclusion: ORP4 is a sterol and PI-4P-binding protein required for survival and proliferation of immortalized and transformed cells. Significance: This is the first study to identify a mammalian ORP with growth regulatory activity.
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U2 - 10.1074/jbc.M114.571216
DO - 10.1074/jbc.M114.571216
M3 - Article
C2 - 24742681
AN - SCOPUS:84901718513
SN - 0021-9258
VL - 289
SP - 15705
EP - 15717
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 22
ER -