Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Kamilia Rizkalla; Sylvia Rodrigues; Alain Proulx; David P. Tingey; J. Godfrey Heathcote

doi:10.1016/S0008-4182(05)80050-X

Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Kamilia Rizkalla, Sylvia Rodrigues, Alain Proulx, David P. Tingey, J. Godfrey Heathcote

Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes. Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression- related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.

Original language	English
Pages (from-to)	585-592
Number of pages	8
Journal	Canadian Journal of Ophthalmology
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/S0008-4182(05)80050-X
Publication status	Published - Oct 2005

ASJC Scopus Subject Areas

Ophthalmology

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abstract = "Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes. Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression- related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.",

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AU - Rodrigues, Sylvia

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AU - Tingey, David P.

AU - Heathcote, J. Godfrey

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N2 - Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes. Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression- related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.

AB - Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes. Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression- related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.

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Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Abstract

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