Prolonged depression of pelvic ganglion transmission - a peripheral manifestation of spinal cord transection

Devany A.S. Twiddy; John W. Downie; Said A. Awad

doi:10.1016/0006-8993(82)90026-9

Prolonged depression of pelvic ganglion transmission - a peripheral manifestation of spinal cord transection

Devany A.S. Twiddy, John W. Downie, Said A. Awad

Research output: Contribution to journal › Article › peer-review

Abstract

Spinal cord transection depressed the bladder's contractile response to pelvic nerve stimulation. This depression was prevented by prior hypogastric nerve section or guanethidine treatment, but was not reversed by the same treatments used after spinal transection. Thus the depression has a peripheral sympathetic basis but is not dependent on ongoing sympathetic nerve activity. Since responses to intra-arterial acetylcholine and dimethylphenylpiperazinium were unchanged by spinal transection, the depression of the pelvic nerve response probably occurs at a ganglion site.

Original language	English
Pages (from-to)	235-239
Number of pages	5
Journal	Brain Research
Volume	231
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90026-9
Publication status	Published - Jan 7 1982
Externally published	Yes

Bibliographical note

Funding Information:
Supported by the Medical Research Council of Canada. Dr. Twiddy was a recipient of a Multiple Sclerosis Society of Canada Research Studentship.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/0006-8993(82)90026-9

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abstract = "Spinal cord transection depressed the bladder's contractile response to pelvic nerve stimulation. This depression was prevented by prior hypogastric nerve section or guanethidine treatment, but was not reversed by the same treatments used after spinal transection. Thus the depression has a peripheral sympathetic basis but is not dependent on ongoing sympathetic nerve activity. Since responses to intra-arterial acetylcholine and dimethylphenylpiperazinium were unchanged by spinal transection, the depression of the pelvic nerve response probably occurs at a ganglion site.",

author = "Twiddy, {Devany A.S.} and Downie, {John W.} and Awad, {Said A.}",

note = "Funding Information: Supported by the Medical Research Council of Canada. Dr. Twiddy was a recipient of a Multiple Sclerosis Society of Canada Research Studentship.",

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AU - Downie, John W.

AU - Awad, Said A.

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PY - 1982/1/7

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N2 - Spinal cord transection depressed the bladder's contractile response to pelvic nerve stimulation. This depression was prevented by prior hypogastric nerve section or guanethidine treatment, but was not reversed by the same treatments used after spinal transection. Thus the depression has a peripheral sympathetic basis but is not dependent on ongoing sympathetic nerve activity. Since responses to intra-arterial acetylcholine and dimethylphenylpiperazinium were unchanged by spinal transection, the depression of the pelvic nerve response probably occurs at a ganglion site.

AB - Spinal cord transection depressed the bladder's contractile response to pelvic nerve stimulation. This depression was prevented by prior hypogastric nerve section or guanethidine treatment, but was not reversed by the same treatments used after spinal transection. Thus the depression has a peripheral sympathetic basis but is not dependent on ongoing sympathetic nerve activity. Since responses to intra-arterial acetylcholine and dimethylphenylpiperazinium were unchanged by spinal transection, the depression of the pelvic nerve response probably occurs at a ganglion site.

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Prolonged depression of pelvic ganglion transmission - a peripheral manifestation of spinal cord transection

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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