Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

M. E.M. Kelly; A. G.M. Bulloch; K. Lukowiak; M. A. Bisby

doi:10.1016/0006-8993(89)91428-5

Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

M. E.M. Kelly, A. G.M. Bulloch, K. Lukowiak, M. A. Bisby

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.

Original language	English
Pages (from-to)	363-368
Number of pages	6
Journal	Brain Research
Volume	477
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)91428-5
Publication status	Published - Jan 16 1989
Externally published	Yes

Bibliographical note

Funding Information:
This work was sepported by the Medical Research Council of Canada. M.E.M.K. was an Alberta Heritage Foundation for Medical Research Fellow and A.G.M.B. is an AHFMR Scholar.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/0006-8993(89)91428-5

Cite this

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title = "Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites",

abstract = "Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.",

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AU - Lukowiak, K.

AU - Bisby, M. A.

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AB - Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.

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Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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