Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

M. E.M. Kelly; A. G.M. Bulloch; K. Lukowiak; M. A. Bisby

doi:10.1016/0006-8993(89)91428-5

Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

M. E.M. Kelly, A. G.M. Bulloch, K. Lukowiak, M. A. Bisby

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14 Citations (Scopus)

Résumé

Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.

Langue d'origine	English
Pages (de-à)	363-368
Nombre de pages	6
Journal	Brain Research
Volume	477
Numéro de publication	1-2
DOI	https://doi.org/10.1016/0006-8993(89)91428-5
Statut de publication	Published - janv. 16 1989
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was sepported by the Medical Research Council of Canada. M.E.M.K. was an Alberta Heritage Foundation for Medical Research Fellow and A.G.M.B. is an AHFMR Scholar.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1016/0006-8993(89)91428-5

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title = "Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites",

abstract = "Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.",

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AU - Lukowiak, K.

AU - Bisby, M. A.

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AB - Regeneration of frog sympathetic neurons (B-cells) was found to be accompanied by sprouting of neurites within the ganglion. Neurons whose axons had been crushed and allowed to regenerate exhibited sprouts that arose mainly from the axon hillock and initial segment of the axon. Sprouting was apparent by 5-7 days and reached maximal values by 14-21 days, but had decreased to control levels by 42-49 days after injury. In contrast, neurons whose axons were prevented from regenerating (by cut and proximal ligation of nerves) exhibited sprouts which did not retract by 42-49 days. These results suggest that successful regeneration to targets may dictate the recovery of normal B-cell morphology in bullfrog sympathetic ganglia.

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Regeneration of frog sympathetic neurons is accompanied by sprouting and retraction of intraganglionic neurites

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

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