Abstract
We carried out a study to determine which of the liver function tests was the most sensitive and/or specific in detecting parenteral nutrition associated cholestasis. The tests utilized were alkaline phosphatase, γ-glutamyl transpeptidase, cholylglycine, sulfolithocholylglycine, and bilirubin. Fifty-nine patients with no prior evidence of liver dysfunction were studied. We found γ-glutamyl transpeptidase to be the most sensitive (89.5%) and also the least specific (61.9% specificity). Specificity of γ-glutamyl transpeptidase was improved when it was combined with alkaline phosphatase. We recommend the combination of these two enzymes as the most cost effective way of detecting parenteral nutrition-associated cholestasis.
| Original language | English |
|---|---|
| Pages (from-to) | 307-308 |
| Number of pages | 2 |
| Journal | Journal of Parenteral and Enteral Nutrition |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1985 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Nanji, A. A., & Anderson, F. H. (1985). Sensitivity and specificity of liver function tests in the detection of parenteral nutrition-associated cholestasis. Journal of Parenteral and Enteral Nutrition, 9(3), 307-308. https://doi.org/10.1177/0148607185009003307