Sensitivity and specificity of liver function tests in the detection of parenteral nutrition-associated cholestasis

A. A. Nanji, F. H. Anderson

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51 Citas (Scopus)

Resumen

We carried out a study to determine which of the liver function tests was the most sensitive and/or specific in detecting parenteral nutrition associated cholestasis. The tests utilized were alkaline phosphatase, γ-glutamyl transpeptidase, cholylglycine, sulfolithocholylglycine, and bilirubin. Fifty-nine patients with no prior evidence of liver dysfunction were studied. We found γ-glutamyl transpeptidase to be the most sensitive (89.5%) and also the least specific (61.9% specificity). Specificity of γ-glutamyl transpeptidase was improved when it was combined with alkaline phosphatase. We recommend the combination of these two enzymes as the most cost effective way of detecting parenteral nutrition-associated cholestasis.

Idioma originalEnglish
Páginas (desde-hasta)307-308
Número de páginas2
PublicaciónJournal of Parenteral and Enteral Nutrition
Volumen9
N.º3
DOI
EstadoPublished - 1985
Publicado de forma externa

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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