SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

D. H. Sandberg; C. W. Bernstein; R. M. McIntosh; R. Carr; J. Strauss

doi:10.1016/S0140-6736(77)92603-4

SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

D. H. Sandberg, C. W. Bernstein, R. M. McIntosh, R. Carr, J. Strauss

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Sensitivity to cow's whole milk was investigated in six patients with the idiopathic nephrotic syndrome of childhood. Prednisone was discontinued and an elemental diet was given. After proteinuria had decreased to ≤500 mg/24 hours on consecutive days patients were challenged with cow's milk. This resulted in the return of significant proteinuria, œdema, and decreased urine volume together with a decrease in serum-IgG concentrations in four patients. Acute alteration of plasma C3 complement component accompanied milk challenge in all 6 patients. There were no consistent alterations in other immunoglobulin concentrations. Intradermal skin testing with cow's milk extract was positive in all patients. These results suggest that in some individuals clinical and biochemical manifestations of the nephrotic syndrome of childhood may be related to hypersensitivity to food products.

Original language	English
Pages (from-to)	388-391
Number of pages	4
Journal	The Lancet
Volume	309
Issue number	8008
DOIs	https://doi.org/10.1016/S0140-6736(77)92603-4
Publication status	Published - Feb 19 1977
Externally published	Yes

Bibliographical note

Funding Information:
Hudson, Alder Hey Hospital, Liverpool, gave us much encouragement. The National Tissue Typing Reference Laboratory, Bristol, supplied HLA typmg antisera. R.L. was supported by a grant from the Medical Research Council.

ASJC Scopus Subject Areas

General Medicine

PubMed: MeSH publication types

Journal Article
Research Support, U.S. Gov't, P.H.S.

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title = "SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY",

abstract = "Sensitivity to cow's whole milk was investigated in six patients with the idiopathic nephrotic syndrome of childhood. Prednisone was discontinued and an elemental diet was given. After proteinuria had decreased to ≤500 mg/24 hours on consecutive days patients were challenged with cow's milk. This resulted in the return of significant proteinuria, {\oe}dema, and decreased urine volume together with a decrease in serum-IgG concentrations in four patients. Acute alteration of plasma C3 complement component accompanied milk challenge in all 6 patients. There were no consistent alterations in other immunoglobulin concentrations. Intradermal skin testing with cow's milk extract was positive in all patients. These results suggest that in some individuals clinical and biochemical manifestations of the nephrotic syndrome of childhood may be related to hypersensitivity to food products.",

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note = "Funding Information: Hudson, Alder Hey Hospital, Liverpool, gave us much encouragement. The National Tissue Typing Reference Laboratory, Bristol, supplied HLA typmg antisera. R.L. was supported by a grant from the Medical Research Council.",

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AU - McIntosh, R. M.

AU - Carr, R.

AU - Strauss, J.

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SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Access to Document

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