SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

D. H. Sandberg; C. W. Bernstein; R. M. McIntosh; R. Carr; J. Strauss

doi:10.1016/S0140-6736(77)92603-4

SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

D. H. Sandberg, C. W. Bernstein, R. M. McIntosh, R. Carr, J. Strauss

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80 Citas (Scopus)

Resumen

Sensitivity to cow's whole milk was investigated in six patients with the idiopathic nephrotic syndrome of childhood. Prednisone was discontinued and an elemental diet was given. After proteinuria had decreased to ≤500 mg/24 hours on consecutive days patients were challenged with cow's milk. This resulted in the return of significant proteinuria, œdema, and decreased urine volume together with a decrease in serum-IgG concentrations in four patients. Acute alteration of plasma C3 complement component accompanied milk challenge in all 6 patients. There were no consistent alterations in other immunoglobulin concentrations. Intradermal skin testing with cow's milk extract was positive in all patients. These results suggest that in some individuals clinical and biochemical manifestations of the nephrotic syndrome of childhood may be related to hypersensitivity to food products.

Idioma original	English
Páginas (desde-hasta)	388-391
Número de páginas	4
Publicación	The Lancet
Volumen	309
N.º	8008
DOI	https://doi.org/10.1016/S0140-6736(77)92603-4
Estado	Published - feb. 19 1977
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
Hudson, Alder Hey Hospital, Liverpool, gave us much encouragement. The National Tissue Typing Reference Laboratory, Bristol, supplied HLA typmg antisera. R.L. was supported by a grant from the Medical Research Council.

ASJC Scopus Subject Areas

General Medicine

PubMed: MeSH publication types

Journal Article
Research Support, U.S. Gov't, P.H.S.

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10.1016/S0140-6736(77)92603-4

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title = "SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY",

abstract = "Sensitivity to cow's whole milk was investigated in six patients with the idiopathic nephrotic syndrome of childhood. Prednisone was discontinued and an elemental diet was given. After proteinuria had decreased to ≤500 mg/24 hours on consecutive days patients were challenged with cow's milk. This resulted in the return of significant proteinuria, {\oe}dema, and decreased urine volume together with a decrease in serum-IgG concentrations in four patients. Acute alteration of plasma C3 complement component accompanied milk challenge in all 6 patients. There were no consistent alterations in other immunoglobulin concentrations. Intradermal skin testing with cow's milk extract was positive in all patients. These results suggest that in some individuals clinical and biochemical manifestations of the nephrotic syndrome of childhood may be related to hypersensitivity to food products.",

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AU - Carr, R.

AU - Strauss, J.

N1 - Funding Information: Hudson, Alder Hey Hospital, Liverpool, gave us much encouragement. The National Tissue Typing Reference Laboratory, Bristol, supplied HLA typmg antisera. R.L. was supported by a grant from the Medical Research Council.

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AB - Sensitivity to cow's whole milk was investigated in six patients with the idiopathic nephrotic syndrome of childhood. Prednisone was discontinued and an elemental diet was given. After proteinuria had decreased to ≤500 mg/24 hours on consecutive days patients were challenged with cow's milk. This resulted in the return of significant proteinuria, œdema, and decreased urine volume together with a decrease in serum-IgG concentrations in four patients. Acute alteration of plasma C3 complement component accompanied milk challenge in all 6 patients. There were no consistent alterations in other immunoglobulin concentrations. Intradermal skin testing with cow's milk extract was positive in all patients. These results suggest that in some individuals clinical and biochemical manifestations of the nephrotic syndrome of childhood may be related to hypersensitivity to food products.

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SEVERE STEROID-RESPONSIVE NEPHROSIS ASSOCIATED WITH HYPERSENSITIVITY

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Acceder al documento

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Huella

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