Suprachiasmatic stimulation phase shifts rodent circadian rhythms

Benjamin Rusak; Gerard Groos

doi:10.1126/science.7063851

Suprachiasmatic stimulation phase shifts rodent circadian rhythms

Benjamin Rusak, Gerard Groos

Medicine

Medicine

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104 Citations (Scopus)

Abstract

The integrity of the suprachiasmatic nuclei (SCN) of the hypothalamus is essential to the expression of normal circadian rhythms in rodents. Electrical stimulation of the SCN caused phase shifts and period changes in the freerunning feeding rhythms of rats and activity rhythms of hamsters. The phase response curve for SCN stimulation appears to parallel that for light pulses. These findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.

Original language	English
Pages (from-to)	1407-1409
Number of pages	3
Journal	Science
Volume	215
Issue number	4538
DOIs	https://doi.org/10.1126/science.7063851
Publication status	Published - 1982

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Journal Article
Research Support, Non-U.S. Gov't

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title = "Suprachiasmatic stimulation phase shifts rodent circadian rhythms",

abstract = "The integrity of the suprachiasmatic nuclei (SCN) of the hypothalamus is essential to the expression of normal circadian rhythms in rodents. Electrical stimulation of the SCN caused phase shifts and period changes in the freerunning feeding rhythms of rats and activity rhythms of hamsters. The phase response curve for SCN stimulation appears to parallel that for light pulses. These findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.",

author = "Benjamin Rusak and Gerard Groos",

year = "1982",

doi = "10.1126/science.7063851",

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AU - Groos, Gerard

PY - 1982

Y1 - 1982

N2 - The integrity of the suprachiasmatic nuclei (SCN) of the hypothalamus is essential to the expression of normal circadian rhythms in rodents. Electrical stimulation of the SCN caused phase shifts and period changes in the freerunning feeding rhythms of rats and activity rhythms of hamsters. The phase response curve for SCN stimulation appears to parallel that for light pulses. These findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.

AB - The integrity of the suprachiasmatic nuclei (SCN) of the hypothalamus is essential to the expression of normal circadian rhythms in rodents. Electrical stimulation of the SCN caused phase shifts and period changes in the freerunning feeding rhythms of rats and activity rhythms of hamsters. The phase response curve for SCN stimulation appears to parallel that for light pulses. These findings strengthen the hypothesis derived from lesion studies that the SCN are the dominant light-entrained oscillators in the rodent circadian system.

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DO - 10.1126/science.7063851

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EP - 1409

JO - Science

JF - Science

IS - 4538

ER -

Suprachiasmatic stimulation phase shifts rodent circadian rhythms

Abstract

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