The effect of myocardial force on coronary transmural flow distribution

Gerald A. Klassen; Danuta T. Zborowska-Sluis

doi:10.1093/cvr/13.7.365

The effect of myocardial force on coronary transmural flow distribution

Gerald A. Klassen, Danuta T. Zborowska-Sluis

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Summary: The role of myocardial force as a determinant of transmural coronary flow distribution was examined in the presence and absence of autoregulation by infusing calcium chloride into a segment of the left coronary system. The concentration of calcium used was adequate to increase force but did not alter coronary pressure or endoventricular pressure. No alterations in transmural gradients of flow were observed following increased regional force. These results suggest that increases in regional force are not of importance as a determinant of transmural blood flow.

Original language	English
Pages (from-to)	365-369
Number of pages	5
Journal	Cardiovascular Research
Volume	13
Issue number	7
DOIs	https://doi.org/10.1093/cvr/13.7.365
Publication status	Published - Jul 1979
Externally published	Yes

Bibliographical note

Funding Information:
Supported by grants from the Medical Research Council of Canada, MT 3238 and the Quebec Heart Foundation.

ASJC Scopus Subject Areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1093/cvr/13.7.365

Cite this

@article{c2616b9b4cc94b2e9fe66ba8e3ace9f3,

title = "The effect of myocardial force on coronary transmural flow distribution",

abstract = "Summary: The role of myocardial force as a determinant of transmural coronary flow distribution was examined in the presence and absence of autoregulation by infusing calcium chloride into a segment of the left coronary system. The concentration of calcium used was adequate to increase force but did not alter coronary pressure or endoventricular pressure. No alterations in transmural gradients of flow were observed following increased regional force. These results suggest that increases in regional force are not of importance as a determinant of transmural blood flow.",

author = "Klassen, {Gerald A.} and Zborowska-Sluis, {Danuta T.}",

note = "Funding Information: Supported by grants from the Medical Research Council of Canada, MT 3238 and the Quebec Heart Foundation.",

year = "1979",

month = jul,

doi = "10.1093/cvr/13.7.365",

language = "English",

volume = "13",

pages = "365--369",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - The effect of myocardial force on coronary transmural flow distribution

AU - Klassen, Gerald A.

AU - Zborowska-Sluis, Danuta T.

N1 - Funding Information: Supported by grants from the Medical Research Council of Canada, MT 3238 and the Quebec Heart Foundation.

PY - 1979/7

Y1 - 1979/7

N2 - Summary: The role of myocardial force as a determinant of transmural coronary flow distribution was examined in the presence and absence of autoregulation by infusing calcium chloride into a segment of the left coronary system. The concentration of calcium used was adequate to increase force but did not alter coronary pressure or endoventricular pressure. No alterations in transmural gradients of flow were observed following increased regional force. These results suggest that increases in regional force are not of importance as a determinant of transmural blood flow.

AB - Summary: The role of myocardial force as a determinant of transmural coronary flow distribution was examined in the presence and absence of autoregulation by infusing calcium chloride into a segment of the left coronary system. The concentration of calcium used was adequate to increase force but did not alter coronary pressure or endoventricular pressure. No alterations in transmural gradients of flow were observed following increased regional force. These results suggest that increases in regional force are not of importance as a determinant of transmural blood flow.

UR - http://www.scopus.com/inward/record.url?scp=85047680941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047680941&partnerID=8YFLogxK

U2 - 10.1093/cvr/13.7.365

DO - 10.1093/cvr/13.7.365

M3 - Review article

C2 - 487378

AN - SCOPUS:85047680941

SN - 0008-6363

VL - 13

SP - 365

EP - 369

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 7

ER -

The effect of myocardial force on coronary transmural flow distribution

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this