The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Sarah K.A. Savoy; Jeanette E. Boudreau

doi:10.3390/v11100959

The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Sarah K.A. Savoy, Jeanette E. Boudreau

Medicine

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA genes segregate independently, thus creating an array of reactive potentials within and between the NK cell repertoires of individuals. In this review, we discuss the interplay between NK cell education and adaptation with virus infection, with a special focus on three viruses for which the NK cell response is often studied: human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the complex co-evolution of viruses and NK cells, and their impact on viral control.

Original language	English
Article number	959
Journal	Viruses
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/v11100959
Publication status	Published - Oct 17 2019

Bibliographical note

Funding Information:
Funding: The work is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC funding reference number RGPIN-2017-06489) to J.E.B., an NSERC Undergraduate Student Research Award to S.K.A.S. and the Banting Research Foundation Discovery award to J.E.B. We gratefully acknowledge Designs that Cell for assistance with our artwork.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v11100959

Cite this

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abstract = "Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education. The KIR and HLA genes segregate independently, thus creating an array of reactive potentials within and between the NK cell repertoires of individuals. In this review, we discuss the interplay between NK cell education and adaptation with virus infection, with a special focus on three viruses for which the NK cell response is often studied: human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). Through this lens, we highlight the complex co-evolution of viruses and NK cells, and their impact on viral control.",

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The evolutionary arms race between virus and NK cells: Diversity enables population-level virus control

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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