TY - JOUR
T1 - The Prevention and Management of Infections in Children with Asplenia or Hyposplenia
AU - Price, Victoria E.
AU - Blanchette, Victor S.
AU - Ford-Jones, E. Lee
PY - 2007/9
Y1 - 2007/9
N2 - Overwhelming sepsis remains a significant complication of asplenia and hyposplenia. The mainstays of prevention are education, immunization, and prophylactic antibiotics. Evidence to base recommendation and guidelines is lacking. Such decisions as the specific immunizations required, the timing of immunizations, the duration of antibiotic prophylaxis, and the prevention of overwhelming postsplenectomy sepsis in children undergoing splenectomy are often empiric. This article reviews the current literature on the prevention and management of severe infections in children with underlying asplenia or hyposplenia.
AB - Overwhelming sepsis remains a significant complication of asplenia and hyposplenia. The mainstays of prevention are education, immunization, and prophylactic antibiotics. Evidence to base recommendation and guidelines is lacking. Such decisions as the specific immunizations required, the timing of immunizations, the duration of antibiotic prophylaxis, and the prevention of overwhelming postsplenectomy sepsis in children undergoing splenectomy are often empiric. This article reviews the current literature on the prevention and management of severe infections in children with underlying asplenia or hyposplenia.
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U2 - 10.1016/j.idc.2007.07.002
DO - 10.1016/j.idc.2007.07.002
M3 - Review article
C2 - 17826619
AN - SCOPUS:34548487557
SN - 0891-5520
VL - 21
SP - 697
EP - 710
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
IS - 3
ER -
