Topical Analgesics

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Topical analgesics are applied to the skin and produce a localized effect on sensory nerve endings to inhibit pain signaling in the periphery. This approach offers the advantage of few systemic adverse effects. There is clear evidence that topical NSAIDs produce analgesia, especially in osteoarthritis. Topical local anesthetics produce pain relief in post-herpetic neuralgia and focal neuropathies. Both classes of drug have entered treatment algorithms as early treatment options. Topical capsaicin produces analgesia in neuropathic pain, but use is limited by local adverse effects and it is considered a third-line treatment. There is less evidence for benefit from rubefacients in chronic pain. Opioids exhibit peripheral analgesia with arthroscopic knee surgery and chronic knee inflammation conditions, and topical applications appear promising for wounds and oral mucosa lesions. The realm of topical analgesics is receiving considerable attention, and several novel targets are being explored for efficacy.

Original languageEnglish
Title of host publicationClinical Pain Management
Subtitle of host publicationA Practical Guide
PublisherWiley-Blackwell
Pages135-141
Number of pages7
ISBN (Print)9781444330694
DOIs
Publication statusPublished - Nov 16 2010

ASJC Scopus Subject Areas

  • General Medicine

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