Topical Analgesics

Producción científica: Capítulo en Libro/Reporte/Acta de conferenciaCapítulo

4 Citas (Scopus)

Resumen

Topical analgesics are applied to the skin and produce a localized effect on sensory nerve endings to inhibit pain signaling in the periphery. This approach offers the advantage of few systemic adverse effects. There is clear evidence that topical NSAIDs produce analgesia, especially in osteoarthritis. Topical local anesthetics produce pain relief in post-herpetic neuralgia and focal neuropathies. Both classes of drug have entered treatment algorithms as early treatment options. Topical capsaicin produces analgesia in neuropathic pain, but use is limited by local adverse effects and it is considered a third-line treatment. There is less evidence for benefit from rubefacients in chronic pain. Opioids exhibit peripheral analgesia with arthroscopic knee surgery and chronic knee inflammation conditions, and topical applications appear promising for wounds and oral mucosa lesions. The realm of topical analgesics is receiving considerable attention, and several novel targets are being explored for efficacy.

Idioma originalEnglish
Título de la publicación alojadaClinical Pain Management
Subtítulo de la publicación alojadaA Practical Guide
EditorialWiley-Blackwell
Páginas135-141
Número de páginas7
ISBN (versión impresa)9781444330694
DOI
EstadoPublished - nov. 16 2010

ASJC Scopus Subject Areas

  • General Medicine

Huella

Profundice en los temas de investigación de 'Topical Analgesics'. En conjunto forman una huella única.

Citar esto