Ubiquitin ligases mediate growth and development by promoting protein death

Sophia L. Stone; Judy Callis

doi:10.1016/j.pbi.2007.07.010

Ubiquitin ligases mediate growth and development by promoting protein death

Sophia L. Stone, Judy Callis

Medicine

Research output: Contribution to journal › Review article › peer-review

154 Citations (Scopus)

Abstract

The ubiquitin proteasome system (UPS) allows plants to effectively and efficiently alter their proteome so as to ensure developmental plasticity and environmental adaptation. Recent work has demonstrated that the UPS is an integral part of multiple hormone-signaling pathways, which modulate cell growth and differentiation. In response to variation in hormone levels, the UPS regulates the abundance of signaling factors, mainly hormone-responsive transcription factors, which mediate cellular responses. Recent exciting studies have shown that hormones directly or indirectly modulate substrate ubiquitination by regulating E3-substrate interaction. Other avenues of regulation include regulating E3 mRNA abundance.

Original language	English
Pages (from-to)	624-632
Number of pages	9
Journal	Current Opinion in Plant Biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.pbi.2007.07.010
Publication status	Published - Dec 2007

Bibliographical note

Funding Information:
The authors apologize to those whose work could not be included because of space constraints. The authors would like to thank Sara Hotton for comments. Research in Callis laboratory is supported by the National Science Foundation (2010 Program MCB-0519970) and the Department of Energy (DE-FG02-03ER15416). Research in the Stone laboratory is supported by the Natural Sciences and Engineering Research Council of Canada and the Human Frontier Science Program.

ASJC Scopus Subject Areas

Plant Science

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10.1016/j.pbi.2007.07.010

Cite this

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title = "Ubiquitin ligases mediate growth and development by promoting protein death",

abstract = "The ubiquitin proteasome system (UPS) allows plants to effectively and efficiently alter their proteome so as to ensure developmental plasticity and environmental adaptation. Recent work has demonstrated that the UPS is an integral part of multiple hormone-signaling pathways, which modulate cell growth and differentiation. In response to variation in hormone levels, the UPS regulates the abundance of signaling factors, mainly hormone-responsive transcription factors, which mediate cellular responses. Recent exciting studies have shown that hormones directly or indirectly modulate substrate ubiquitination by regulating E3-substrate interaction. Other avenues of regulation include regulating E3 mRNA abundance.",

author = "Stone, {Sophia L.} and Judy Callis",

note = "Funding Information: The authors apologize to those whose work could not be included because of space constraints. The authors would like to thank Sara Hotton for comments. Research in Callis laboratory is supported by the National Science Foundation (2010 Program MCB-0519970) and the Department of Energy (DE-FG02-03ER15416). Research in the Stone laboratory is supported by the Natural Sciences and Engineering Research Council of Canada and the Human Frontier Science Program.",

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doi = "10.1016/j.pbi.2007.07.010",

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AU - Callis, Judy

N1 - Funding Information: The authors apologize to those whose work could not be included because of space constraints. The authors would like to thank Sara Hotton for comments. Research in Callis laboratory is supported by the National Science Foundation (2010 Program MCB-0519970) and the Department of Energy (DE-FG02-03ER15416). Research in the Stone laboratory is supported by the Natural Sciences and Engineering Research Council of Canada and the Human Frontier Science Program.

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AB - The ubiquitin proteasome system (UPS) allows plants to effectively and efficiently alter their proteome so as to ensure developmental plasticity and environmental adaptation. Recent work has demonstrated that the UPS is an integral part of multiple hormone-signaling pathways, which modulate cell growth and differentiation. In response to variation in hormone levels, the UPS regulates the abundance of signaling factors, mainly hormone-responsive transcription factors, which mediate cellular responses. Recent exciting studies have shown that hormones directly or indirectly modulate substrate ubiquitination by regulating E3-substrate interaction. Other avenues of regulation include regulating E3 mRNA abundance.

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Ubiquitin ligases mediate growth and development by promoting protein death

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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