Ubiquitin ligases mediate growth and development by promoting protein death

Sophia L. Stone; Judy Callis

doi:10.1016/j.pbi.2007.07.010

Ubiquitin ligases mediate growth and development by promoting protein death

Sophia L. Stone, Judy Callis

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

154 Citas (Scopus)

Resumen

The ubiquitin proteasome system (UPS) allows plants to effectively and efficiently alter their proteome so as to ensure developmental plasticity and environmental adaptation. Recent work has demonstrated that the UPS is an integral part of multiple hormone-signaling pathways, which modulate cell growth and differentiation. In response to variation in hormone levels, the UPS regulates the abundance of signaling factors, mainly hormone-responsive transcription factors, which mediate cellular responses. Recent exciting studies have shown that hormones directly or indirectly modulate substrate ubiquitination by regulating E3-substrate interaction. Other avenues of regulation include regulating E3 mRNA abundance.

Idioma original	English
Páginas (desde-hasta)	624-632
Número de páginas	9
Publicación	Current Opinion in Plant Biology
Volumen	10
N.º	6
DOI	https://doi.org/10.1016/j.pbi.2007.07.010
Estado	Published - dic. 2007

Nota bibliográfica

Funding Information:
The authors apologize to those whose work could not be included because of space constraints. The authors would like to thank Sara Hotton for comments. Research in Callis laboratory is supported by the National Science Foundation (2010 Program MCB-0519970) and the Department of Energy (DE-FG02-03ER15416). Research in the Stone laboratory is supported by the Natural Sciences and Engineering Research Council of Canada and the Human Frontier Science Program.

ASJC Scopus Subject Areas

Plant Science

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10.1016/j.pbi.2007.07.010

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title = "Ubiquitin ligases mediate growth and development by promoting protein death",

abstract = "The ubiquitin proteasome system (UPS) allows plants to effectively and efficiently alter their proteome so as to ensure developmental plasticity and environmental adaptation. Recent work has demonstrated that the UPS is an integral part of multiple hormone-signaling pathways, which modulate cell growth and differentiation. In response to variation in hormone levels, the UPS regulates the abundance of signaling factors, mainly hormone-responsive transcription factors, which mediate cellular responses. Recent exciting studies have shown that hormones directly or indirectly modulate substrate ubiquitination by regulating E3-substrate interaction. Other avenues of regulation include regulating E3 mRNA abundance.",

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Ubiquitin ligases mediate growth and development by promoting protein death

Resumen

Nota bibliográfica

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