Ching, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abé, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., Eyler, L. T., Favre, P., Hajek, T., Haukvik, U. K., Houenou, J., Landén, M., Lett, T. A., McDonald, C., Nabulsi, L., ... Andreassen, O. A. (Accepted/In press). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping. https://doi.org/10.1002/hbm.25098
Ching, CRK, Hibar, DP, Gurholt, TP, Nunes, A, Thomopoulos, SI, Abé, C, Agartz, I, Brouwer, RM, Cannon, DM, de Zwarte, SMC, Eyler, LT, Favre, P, Hajek, T, Haukvik, UK, Houenou, J, Landén, M, Lett, TA, McDonald, C, Nabulsi, L, Patel, Y, Pauling, ME, Paus, T, Radua, J, Soeiro-de-Souza, MG, Tronchin, G, van Haren, NEM, Vieta, E, Walter, H, Zeng, LL, Alda, M, Almeida, J, Alnæs, D, Alonso-Lana, S, Altimus, C, Bauer, M, Baune, BT, Bearden, CE, Bellani, M, Benedetti, F, Berk, M, Bilderbeck, AC, Blumberg, HP, Bøen, E, Bollettini, I, del Mar Bonnin, C, Brambilla, P, Canales-Rodríguez, EJ, Caseras, X, Dandash, O, Dannlowski, U, Delvecchio, G, Díaz-Zuluaga, AM, Dima, D, Duchesnay, É, Elvsåshagen, T, Fears, SC, Frangou, S, Fullerton, JM, Glahn, DC, Goikolea, JM, Green, MJ, Grotegerd, D, Gruber, O, Haarman, BCM, Henry, C, Howells, FM, Ives-Deliperi, V, Jansen, A, Kircher, TTJ, Knöchel, C, Kramer, B, Lafer, B, López-Jaramillo, C, Machado-Vieira, R, MacIntosh, BJ, Melloni, EMT, Mitchell, PB, Nenadic, I, Nery, F, Nugent, AC, Oertel, V, Ophoff, RA, Ota, M, Overs, BJ, Pham, DL, Phillips, ML, Pineda-Zapata, JA, Poletti, S, Polosan, M, Pomarol-Clotet, E, Pouchon, A, Quidé, Y, Rive, MM, Roberts, G, Ruhe, HG, Salvador, R, Sarró, S, Satterthwaite, TD, Schene, AH, Sim, K, Soares, JC, Stäblein, M, Stein, DJ, Tamnes, CK, Thomaidis, GV, Upegui, CV, Veltman, DJ, Wessa, M, Westlye, LT, Whalley, HC, Wolf, DH, Wu, MJ, Yatham, LN, Zarate, CA, Thompson, PM & Andreassen, OA 2020, 'What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group', Human Brain Mapping. https://doi.org/10.1002/hbm.25098
@article{ed358d77d88149a99e7cdb490c4f4957,
title = "What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group",
abstract = "MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.",
author = "Ching, {Christopher R.K.} and Hibar, {Derrek P.} and Gurholt, {Tiril P.} and Abraham Nunes and Thomopoulos, {Sophia I.} and Christoph Ab{\'e} and Ingrid Agartz and Brouwer, {Rachel M.} and Cannon, {Dara M.} and {de Zwarte}, {Sonja M.C.} and Eyler, {Lisa T.} and Pauline Favre and Tomas Hajek and Haukvik, {Unn K.} and Josselin Houenou and Mikael Land{\'e}n and Lett, {Tristram A.} and Colm McDonald and Leila Nabulsi and Yash Patel and Pauling, {Melissa E.} and Tomas Paus and Joaquim Radua and Soeiro-de-Souza, {Marcio G.} and Giulia Tronchin and {van Haren}, {Neeltje E.M.} and Eduard Vieta and Henrik Walter and Zeng, {Ling Li} and Martin Alda and Jorge Almeida and Dag Aln{\ae}s and Silvia Alonso-Lana and Cara Altimus and Michael Bauer and Baune, {Bernhard T.} and Bearden, {Carrie E.} and Marcella Bellani and Francesco Benedetti and Michael Berk and Bilderbeck, {Amy C.} and Blumberg, {Hilary P.} and Erlend B{\o}en and Irene Bollettini and {del Mar Bonnin}, Caterina and Paolo Brambilla and Canales-Rodr{\'i}guez, {Erick J.} and Xavier Caseras and Orwa Dandash and Udo Dannlowski and Giuseppe Delvecchio and D{\'i}az-Zuluaga, {Ana M.} and Danai Dima and {\'E}douard Duchesnay and Torbj{\o}rn Elvs{\aa}shagen and Fears, {Scott C.} and Sophia Frangou and Fullerton, {Janice M.} and Glahn, {David C.} and Goikolea, {Jose M.} and Green, {Melissa J.} and Dominik Grotegerd and Oliver Gruber and Haarman, {Bartholomeus C.M.} and Chantal Henry and Howells, {Fleur M.} and Victoria Ives-Deliperi and Andreas Jansen and Kircher, {Tilo T.J.} and Christian Kn{\"o}chel and Bernd Kramer and Beny Lafer and Carlos L{\'o}pez-Jaramillo and Rodrigo Machado-Vieira and MacIntosh, {Bradley J.} and Melloni, {Elisa M.T.} and Mitchell, {Philip B.} and Igor Nenadic and Fabiano Nery and Nugent, {Allison C.} and Viola Oertel and Ophoff, {Roel A.} and Miho Ota and Overs, {Bronwyn J.} and Pham, {Daniel L.} and Phillips, {Mary L.} and Pineda-Zapata, {Julian A.} and Sara Poletti and Mircea Polosan and Edith Pomarol-Clotet and Arnaud Pouchon and Yann Quid{\'e} and Rive, {Maria M.} and Gloria Roberts and Ruhe, {Henricus G.} and Raymond Salvador and Salvador Sarr{\'o} and Satterthwaite, {Theodore D.} and Schene, {Aart H.} and Kang Sim and Soares, {Jair C.} and Michael St{\"a}blein and Stein, {Dan J.} and Tamnes, {Christian K.} and Thomaidis, {Georgios V.} and Upegui, {Cristian Vargas} and Veltman, {Dick J.} and Mich{\`e}le Wessa and Westlye, {Lars T.} and Whalley, {Heather C.} and Wolf, {Daniel H.} and Wu, {Mon Ju} and Yatham, {Lakshmi N.} and Zarate, {Carlos A.} and Thompson, {Paul M.} and Andreassen, {Ole A.}",
note = "Funding Information: O. A. A. received Speaker's honorarium from Lundbeck and is a consultant for HealthLytix. M. B. was supported by an unrestricted grant from AstraZeneca. A. C. B. is a full‐time employee of P1vital Ltd. C. R. K. C. and P. M. T. have received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. T. E. has received a speaker's fee from Lundbeck. G. M. G. is a NIHR Emeritus Senior Investigator, holds shares in P1vital and P1Vital products and has served as consultant, advisor or C. M. E. speaker in the last 3 years for Allergan, Angelini, Compass pathways, MSD, Janssen, Lundbeck (/Otsuka or /Takeda), Medscape, Minerva, P1Vital, Pfizer, Sage, Servier, Shire, Sun Pharma. D. P. H. is a full‐time employee of Genentech, Inc. A. M. M. has received research support from the Eli Lilly, Janssen and The Sackler Trust. J. C. S. has participated in research funded by Forest, Merck, BMS, and GSK and has been a speaker for Pfizer and Abbott. Marsal Sanches has received research grants from Janssen. All other authors from this site report no conflicts of interest to declare. D. J. S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. E. V. has received grants and served as consultant, advisor or CME speaker for the following entities (work unrelated to the topic of this manuscript): AB‐Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi‐Aventis, and Takeda. Funding Information: The S{\~a}o Paulo (Brazil) studies have been supported by grants from FAPESP‐Brazil (#2009/14891‐9, 2010/18672‐7, 2012/23796‐2 & 2013/03905‐4), CNPq‐Brazil (#478466/2009 & 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (2010 NARSAD Independent Investigator Award granted to Geraldo F. Busatto). C. A. Z. was supported by Intramural Research Program, National Institute of Mental Health. L.‐L. Z. was supported by National Natural Science Foundation of China (61722313), Fok Ying Tung Education Foundation (161057), and Science & Technology Innovation Program of Hunan Province (2018RS3080). Lastly, we would like to thank all of the ENIGMA Consortium Working Group Members for all their efforts in helping this international consortium effort thrive. Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.",
year = "2020",
doi = "10.1002/hbm.25098",
language = "English",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
}
TY - JOUR
T1 - What we learn about bipolar disorder from large-scale neuroimaging
T2 - Findings and future directions from the ENIGMA Bipolar Disorder Working Group
AU - Ching, Christopher R.K.
AU - Hibar, Derrek P.
AU - Gurholt, Tiril P.
AU - Nunes, Abraham
AU - Thomopoulos, Sophia I.
AU - Abé, Christoph
AU - Agartz, Ingrid
AU - Brouwer, Rachel M.
AU - Cannon, Dara M.
AU - de Zwarte, Sonja M.C.
AU - Eyler, Lisa T.
AU - Favre, Pauline
AU - Hajek, Tomas
AU - Haukvik, Unn K.
AU - Houenou, Josselin
AU - Landén, Mikael
AU - Lett, Tristram A.
AU - McDonald, Colm
AU - Nabulsi, Leila
AU - Patel, Yash
AU - Pauling, Melissa E.
AU - Paus, Tomas
AU - Radua, Joaquim
AU - Soeiro-de-Souza, Marcio G.
AU - Tronchin, Giulia
AU - van Haren, Neeltje E.M.
AU - Vieta, Eduard
AU - Walter, Henrik
AU - Zeng, Ling Li
AU - Alda, Martin
AU - Almeida, Jorge
AU - Alnæs, Dag
AU - Alonso-Lana, Silvia
AU - Altimus, Cara
AU - Bauer, Michael
AU - Baune, Bernhard T.
AU - Bearden, Carrie E.
AU - Bellani, Marcella
AU - Benedetti, Francesco
AU - Berk, Michael
AU - Bilderbeck, Amy C.
AU - Blumberg, Hilary P.
AU - Bøen, Erlend
AU - Bollettini, Irene
AU - del Mar Bonnin, Caterina
AU - Brambilla, Paolo
AU - Canales-Rodríguez, Erick J.
AU - Caseras, Xavier
AU - Dandash, Orwa
AU - Dannlowski, Udo
AU - Delvecchio, Giuseppe
AU - Díaz-Zuluaga, Ana M.
AU - Dima, Danai
AU - Duchesnay, Édouard
AU - Elvsåshagen, Torbjørn
AU - Fears, Scott C.
AU - Frangou, Sophia
AU - Fullerton, Janice M.
AU - Glahn, David C.
AU - Goikolea, Jose M.
AU - Green, Melissa J.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Haarman, Bartholomeus C.M.
AU - Henry, Chantal
AU - Howells, Fleur M.
AU - Ives-Deliperi, Victoria
AU - Jansen, Andreas
AU - Kircher, Tilo T.J.
AU - Knöchel, Christian
AU - Kramer, Bernd
AU - Lafer, Beny
AU - López-Jaramillo, Carlos
AU - Machado-Vieira, Rodrigo
AU - MacIntosh, Bradley J.
AU - Melloni, Elisa M.T.
AU - Mitchell, Philip B.
AU - Nenadic, Igor
AU - Nery, Fabiano
AU - Nugent, Allison C.
AU - Oertel, Viola
AU - Ophoff, Roel A.
AU - Ota, Miho
AU - Overs, Bronwyn J.
AU - Pham, Daniel L.
AU - Phillips, Mary L.
AU - Pineda-Zapata, Julian A.
AU - Poletti, Sara
AU - Polosan, Mircea
AU - Pomarol-Clotet, Edith
AU - Pouchon, Arnaud
AU - Quidé, Yann
AU - Rive, Maria M.
AU - Roberts, Gloria
AU - Ruhe, Henricus G.
AU - Salvador, Raymond
AU - Sarró, Salvador
AU - Satterthwaite, Theodore D.
AU - Schene, Aart H.
AU - Sim, Kang
AU - Soares, Jair C.
AU - Stäblein, Michael
AU - Stein, Dan J.
AU - Tamnes, Christian K.
AU - Thomaidis, Georgios V.
AU - Upegui, Cristian Vargas
AU - Veltman, Dick J.
AU - Wessa, Michèle
AU - Westlye, Lars T.
AU - Whalley, Heather C.
AU - Wolf, Daniel H.
AU - Wu, Mon Ju
AU - Yatham, Lakshmi N.
AU - Zarate, Carlos A.
AU - Thompson, Paul M.
AU - Andreassen, Ole A.
N1 - Funding Information:
O. A. A. received Speaker's honorarium from Lundbeck and is a consultant for HealthLytix. M. B. was supported by an unrestricted grant from AstraZeneca. A. C. B. is a full‐time employee of P1vital Ltd. C. R. K. C. and P. M. T. have received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. T. E. has received a speaker's fee from Lundbeck. G. M. G. is a NIHR Emeritus Senior Investigator, holds shares in P1vital and P1Vital products and has served as consultant, advisor or C. M. E. speaker in the last 3 years for Allergan, Angelini, Compass pathways, MSD, Janssen, Lundbeck (/Otsuka or /Takeda), Medscape, Minerva, P1Vital, Pfizer, Sage, Servier, Shire, Sun Pharma. D. P. H. is a full‐time employee of Genentech, Inc. A. M. M. has received research support from the Eli Lilly, Janssen and The Sackler Trust. J. C. S. has participated in research funded by Forest, Merck, BMS, and GSK and has been a speaker for Pfizer and Abbott. Marsal Sanches has received research grants from Janssen. All other authors from this site report no conflicts of interest to declare. D. J. S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. E. V. has received grants and served as consultant, advisor or CME speaker for the following entities (work unrelated to the topic of this manuscript): AB‐Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi‐Aventis, and Takeda.
Funding Information:
The São Paulo (Brazil) studies have been supported by grants from FAPESP‐Brazil (#2009/14891‐9, 2010/18672‐7, 2012/23796‐2 & 2013/03905‐4), CNPq‐Brazil (#478466/2009 & 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (2010 NARSAD Independent Investigator Award granted to Geraldo F. Busatto). C. A. Z. was supported by Intramural Research Program, National Institute of Mental Health. L.‐L. Z. was supported by National Natural Science Foundation of China (61722313), Fok Ying Tung Education Foundation (161057), and Science & Technology Innovation Program of Hunan Province (2018RS3080). Lastly, we would like to thank all of the ENIGMA Consortium Working Group Members for all their efforts in helping this international consortium effort thrive.
Publisher Copyright:
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
PY - 2020
Y1 - 2020
N2 - MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.
AB - MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.
UR - http://www.scopus.com/inward/record.url?scp=85088655322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088655322&partnerID=8YFLogxK
U2 - 10.1002/hbm.25098
DO - 10.1002/hbm.25098
M3 - Review article
C2 - 32725849
AN - SCOPUS:85088655322
SN - 1065-9471
JO - Human Brain Mapping
JF - Human Brain Mapping
ER -
