What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Christopher R.K. Ching; Derrek P. Hibar; Tiril P. Gurholt; Abraham Nunes; Sophia I. Thomopoulos; Christoph Abé; Ingrid Agartz; Rachel M. Brouwer; Dara M. Cannon; Sonja M.C. de Zwarte; Lisa T. Eyler; Pauline Favre; Tomas Hajek; Unn K. Haukvik; Josselin Houenou; Mikael Landén; Tristram A. Lett; Colm McDonald; Leila Nabulsi; Yash Patel; Melissa E. Pauling; Tomas Paus; Joaquim Radua; Marcio G. Soeiro-de-Souza; Giulia Tronchin; Neeltje E.M. van Haren; Eduard Vieta; Henrik Walter; Ling Li Zeng; Martin Alda; Jorge Almeida; Dag Alnæs; Silvia Alonso-Lana; Cara Altimus; Michael Bauer; Bernhard T. Baune; Carrie E. Bearden; Marcella Bellani; Francesco Benedetti; Michael Berk; Amy C. Bilderbeck; Hilary P. Blumberg; Erlend Bøen; Irene Bollettini; Caterina del Mar Bonnin; Paolo Brambilla; Erick J. Canales-Rodríguez; Xavier Caseras; Orwa Dandash; Udo Dannlowski; Giuseppe Delvecchio; Ana M. Díaz-Zuluaga; Danai Dima; Édouard Duchesnay; Torbjørn Elvsåshagen; Scott C. Fears; Sophia Frangou; Janice M. Fullerton; David C. Glahn; Jose M. Goikolea; Melissa J. Green; Dominik Grotegerd; Oliver Gruber; Bartholomeus C.M. Haarman; Chantal Henry; Fleur M. Howells; Victoria Ives-Deliperi; Andreas Jansen; Tilo T.J. Kircher; Christian Knöchel; Bernd Kramer; Beny Lafer; Carlos López-Jaramillo; Rodrigo Machado-Vieira; Bradley J. MacIntosh; Elisa M.T. Melloni; Philip B. Mitchell; Igor Nenadic; Fabiano Nery; Allison C. Nugent; Viola Oertel; Roel A. Ophoff; Miho Ota; Bronwyn J. Overs; Daniel L. Pham; Mary L. Phillips; Julian A. Pineda-Zapata; Sara Poletti; Mircea Polosan; Edith Pomarol-Clotet; Arnaud Pouchon; Yann Quidé; Maria M. Rive; Gloria Roberts; Henricus G. Ruhe; Raymond Salvador; Salvador Sarró; Theodore D. Satterthwaite; Aart H. Schene; Kang Sim; Jair C. Soares; Michael Stäblein; Dan J. Stein; Christian K. Tamnes; Georgios V. Thomaidis; Cristian Vargas Upegui; Dick J. Veltman; Michèle Wessa; Lars T. Westlye; Heather C. Whalley; Daniel H. Wolf; Mon Ju Wu; Lakshmi N. Yatham; Carlos A. Zarate; Paul M. Thompson; Ole A. Andreassen

doi:10.1002/hbm.25098

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Christopher R.K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abé, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M.C. de Zwarte, Lisa T. Eyler, Pauline Favre, Tomas Hajek, Unn K. Haukvik, Josselin Houenou, Mikael Landén, Tristram A. Lett, Colm McDonald, Leila Nabulsi, Yash PatelMelissa E. Pauling, Tomas Paus, Joaquim Radua, Marcio G. Soeiro-de-Souza, Giulia Tronchin, Neeltje E.M. van Haren, Eduard Vieta, Henrik Walter, Ling Li Zeng, Martin Alda, Jorge Almeida, Dag Alnæs, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T. Baune, Carrie E. Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C. Bilderbeck, Hilary P. Blumberg, Erlend Bøen, Irene Bollettini, Caterina del Mar Bonnin, Paolo Brambilla, Erick J. Canales-Rodríguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Díaz-Zuluaga, Danai Dima, Édouard Duchesnay, Torbjørn Elvsåshagen, Scott C. Fears, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Jose M. Goikolea, Melissa J. Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C.M. Haarman, Chantal Henry, Fleur M. Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T.J. Kircher, Christian Knöchel, Bernd Kramer, Beny Lafer, Carlos López-Jaramillo, Rodrigo Machado-Vieira, Bradley J. MacIntosh, Elisa M.T. Melloni, Philip B. Mitchell, Igor Nenadic, Fabiano Nery, Allison C. Nugent, Viola Oertel, Roel A. Ophoff, Miho Ota, Bronwyn J. Overs, Daniel L. Pham, Mary L. Phillips, Julian A. Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quidé, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarró, Theodore D. Satterthwaite, Aart H. Schene, Kang Sim, Jair C. Soares, Michael Stäblein, Dan J. Stein, Christian K. Tamnes, Georgios V. Thomaidis, Cristian Vargas Upegui, Dick J. Veltman, Michèle Wessa, Lars T. Westlye, Heather C. Whalley, Daniel H. Wolf, Mon Ju Wu, Lakshmi N. Yatham, Carlos A. Zarate, Paul M. Thompson, Ole A. Andreassen

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

89 Citas (Scopus)

Resumen

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.

Idioma original	English
Publicación	Human Brain Mapping
DOI	https://doi.org/10.1002/hbm.25098
Estado	Accepted/In press - 2020

Nota bibliográfica

Funding Information:
O. A. A. received Speaker's honorarium from Lundbeck and is a consultant for HealthLytix. M. B. was supported by an unrestricted grant from AstraZeneca. A. C. B. is a full‐time employee of P1vital Ltd. C. R. K. C. and P. M. T. have received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. T. E. has received a speaker's fee from Lundbeck. G. M. G. is a NIHR Emeritus Senior Investigator, holds shares in P1vital and P1Vital products and has served as consultant, advisor or C. M. E. speaker in the last 3 years for Allergan, Angelini, Compass pathways, MSD, Janssen, Lundbeck (/Otsuka or /Takeda), Medscape, Minerva, P1Vital, Pfizer, Sage, Servier, Shire, Sun Pharma. D. P. H. is a full‐time employee of Genentech, Inc. A. M. M. has received research support from the Eli Lilly, Janssen and The Sackler Trust. J. C. S. has participated in research funded by Forest, Merck, BMS, and GSK and has been a speaker for Pfizer and Abbott. Marsal Sanches has received research grants from Janssen. All other authors from this site report no conflicts of interest to declare. D. J. S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. E. V. has received grants and served as consultant, advisor or CME speaker for the following entities (work unrelated to the topic of this manuscript): AB‐Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi‐Aventis, and Takeda.

Funding Information:
The São Paulo (Brazil) studies have been supported by grants from FAPESP‐Brazil (#2009/14891‐9, 2010/18672‐7, 2012/23796‐2 & 2013/03905‐4), CNPq‐Brazil (#478466/2009 & 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (2010 NARSAD Independent Investigator Award granted to Geraldo F. Busatto). C. A. Z. was supported by Intramural Research Program, National Institute of Mental Health. L.‐L. Z. was supported by National Natural Science Foundation of China (61722313), Fok Ying Tung Education Foundation (161057), and Science & Technology Innovation Program of Hunan Province (2018RS3080). Lastly, we would like to thank all of the ENIGMA Consortium Working Group Members for all their efforts in helping this international consortium effort thrive.

Publisher Copyright:
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

ASJC Scopus Subject Areas

Anatomy
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

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Ching, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abé, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., Eyler, L. T., Favre, P., Hajek, T., Haukvik, U. K., Houenou, J., Landén, M., Lett, T. A., McDonald, C., Nabulsi, L., ... Andreassen, O. A. (Aceptado/En prensa). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping. https://doi.org/10.1002/hbm.25098

Ching, CRK, Hibar, DP, Gurholt, TP, Nunes, A, Thomopoulos, SI, Abé, C, Agartz, I, Brouwer, RM, Cannon, DM, de Zwarte, SMC, Eyler, LT, Favre, P, Hajek, T, Haukvik, UK, Houenou, J, Landén, M, Lett, TA, McDonald, C, Nabulsi, L, Patel, Y, Pauling, ME, Paus, T, Radua, J, Soeiro-de-Souza, MG, Tronchin, G, van Haren, NEM, Vieta, E, Walter, H, Zeng, LL, Alda, M, Almeida, J, Alnæs, D, Alonso-Lana, S, Altimus, C, Bauer, M, Baune, BT, Bearden, CE, Bellani, M, Benedetti, F, Berk, M, Bilderbeck, AC, Blumberg, HP, Bøen, E, Bollettini, I, del Mar Bonnin, C, Brambilla, P, Canales-Rodríguez, EJ, Caseras, X, Dandash, O, Dannlowski, U, Delvecchio, G, Díaz-Zuluaga, AM, Dima, D, Duchesnay, É, Elvsåshagen, T, Fears, SC, Frangou, S, Fullerton, JM, Glahn, DC, Goikolea, JM, Green, MJ, Grotegerd, D, Gruber, O, Haarman, BCM, Henry, C, Howells, FM, Ives-Deliperi, V, Jansen, A, Kircher, TTJ, Knöchel, C, Kramer, B, Lafer, B, López-Jaramillo, C, Machado-Vieira, R, MacIntosh, BJ, Melloni, EMT, Mitchell, PB, Nenadic, I, Nery, F, Nugent, AC, Oertel, V, Ophoff, RA, Ota, M, Overs, BJ, Pham, DL, Phillips, ML, Pineda-Zapata, JA, Poletti, S, Polosan, M, Pomarol-Clotet, E, Pouchon, A, Quidé, Y, Rive, MM, Roberts, G, Ruhe, HG, Salvador, R, Sarró, S, Satterthwaite, TD, Schene, AH, Sim, K, Soares, JC, Stäblein, M, Stein, DJ, Tamnes, CK, Thomaidis, GV, Upegui, CV, Veltman, DJ, Wessa, M, Westlye, LT, Whalley, HC, Wolf, DH, Wu, MJ, Yatham, LN, Zarate, CA, Thompson, PM & Andreassen, OA 2020, 'What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group', Human Brain Mapping. https://doi.org/10.1002/hbm.25098

@article{ed358d77d88149a99e7cdb490c4f4957,

title = "What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group",

abstract = "MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.",

author = "Ching, {Christopher R.K.} and Hibar, {Derrek P.} and Gurholt, {Tiril P.} and Abraham Nunes and Thomopoulos, {Sophia I.} and Christoph Ab{\'e} and Ingrid Agartz and Brouwer, {Rachel M.} and Cannon, {Dara M.} and {de Zwarte}, {Sonja M.C.} and Eyler, {Lisa T.} and Pauline Favre and Tomas Hajek and Haukvik, {Unn K.} and Josselin Houenou and Mikael Land{\'e}n and Lett, {Tristram A.} and Colm McDonald and Leila Nabulsi and Yash Patel and Pauling, {Melissa E.} and Tomas Paus and Joaquim Radua and Soeiro-de-Souza, {Marcio G.} and Giulia Tronchin and {van Haren}, {Neeltje E.M.} and Eduard Vieta and Henrik Walter and Zeng, {Ling Li} and Martin Alda and Jorge Almeida and Dag Aln{\ae}s and Silvia Alonso-Lana and Cara Altimus and Michael Bauer and Baune, {Bernhard T.} and Bearden, {Carrie E.} and Marcella Bellani and Francesco Benedetti and Michael Berk and Bilderbeck, {Amy C.} and Blumberg, {Hilary P.} and Erlend B{\o}en and Irene Bollettini and {del Mar Bonnin}, Caterina and Paolo Brambilla and Canales-Rodr{\'i}guez, {Erick J.} and Xavier Caseras and Orwa Dandash and Udo Dannlowski and Giuseppe Delvecchio and D{\'i}az-Zuluaga, {Ana M.} and Danai Dima and {\'E}douard Duchesnay and Torbj{\o}rn Elvs{\aa}shagen and Fears, {Scott C.} and Sophia Frangou and Fullerton, {Janice M.} and Glahn, {David C.} and Goikolea, {Jose M.} and Green, {Melissa J.} and Dominik Grotegerd and Oliver Gruber and Haarman, {Bartholomeus C.M.} and Chantal Henry and Howells, {Fleur M.} and Victoria Ives-Deliperi and Andreas Jansen and Kircher, {Tilo T.J.} and Christian Kn{\"o}chel and Bernd Kramer and Beny Lafer and Carlos L{\'o}pez-Jaramillo and Rodrigo Machado-Vieira and MacIntosh, {Bradley J.} and Melloni, {Elisa M.T.} and Mitchell, {Philip B.} and Igor Nenadic and Fabiano Nery and Nugent, {Allison C.} and Viola Oertel and Ophoff, {Roel A.} and Miho Ota and Overs, {Bronwyn J.} and Pham, {Daniel L.} and Phillips, {Mary L.} and Pineda-Zapata, {Julian A.} and Sara Poletti and Mircea Polosan and Edith Pomarol-Clotet and Arnaud Pouchon and Yann Quid{\'e} and Rive, {Maria M.} and Gloria Roberts and Ruhe, {Henricus G.} and Raymond Salvador and Salvador Sarr{\'o} and Satterthwaite, {Theodore D.} and Schene, {Aart H.} and Kang Sim and Soares, {Jair C.} and Michael St{\"a}blein and Stein, {Dan J.} and Tamnes, {Christian K.} and Thomaidis, {Georgios V.} and Upegui, {Cristian Vargas} and Veltman, {Dick J.} and Mich{\`e}le Wessa and Westlye, {Lars T.} and Whalley, {Heather C.} and Wolf, {Daniel H.} and Wu, {Mon Ju} and Yatham, {Lakshmi N.} and Zarate, {Carlos A.} and Thompson, {Paul M.} and Andreassen, {Ole A.}",

note = "Funding Information: O. A. A. received Speaker's honorarium from Lundbeck and is a consultant for HealthLytix. M. B. was supported by an unrestricted grant from AstraZeneca. A. C. B. is a full‐time employee of P1vital Ltd. C. R. K. C. and P. M. T. have received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. T. E. has received a speaker's fee from Lundbeck. G. M. G. is a NIHR Emeritus Senior Investigator, holds shares in P1vital and P1Vital products and has served as consultant, advisor or C. M. E. speaker in the last 3 years for Allergan, Angelini, Compass pathways, MSD, Janssen, Lundbeck (/Otsuka or /Takeda), Medscape, Minerva, P1Vital, Pfizer, Sage, Servier, Shire, Sun Pharma. D. P. H. is a full‐time employee of Genentech, Inc. A. M. M. has received research support from the Eli Lilly, Janssen and The Sackler Trust. J. C. S. has participated in research funded by Forest, Merck, BMS, and GSK and has been a speaker for Pfizer and Abbott. Marsal Sanches has received research grants from Janssen. All other authors from this site report no conflicts of interest to declare. D. J. S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. E. V. has received grants and served as consultant, advisor or CME speaker for the following entities (work unrelated to the topic of this manuscript): AB‐Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi‐Aventis, and Takeda. Funding Information: The S{\~a}o Paulo (Brazil) studies have been supported by grants from FAPESP‐Brazil (#2009/14891‐9, 2010/18672‐7, 2012/23796‐2 & 2013/03905‐4), CNPq‐Brazil (#478466/2009 & 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (2010 NARSAD Independent Investigator Award granted to Geraldo F. Busatto). C. A. Z. was supported by Intramural Research Program, National Institute of Mental Health. L.‐L. Z. was supported by National Natural Science Foundation of China (61722313), Fok Ying Tung Education Foundation (161057), and Science & Technology Innovation Program of Hunan Province (2018RS3080). Lastly, we would like to thank all of the ENIGMA Consortium Working Group Members for all their efforts in helping this international consortium effort thrive. Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.",

year = "2020",

doi = "10.1002/hbm.25098",

language = "English",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - What we learn about bipolar disorder from large-scale neuroimaging

T2 - Findings and future directions from the ENIGMA Bipolar Disorder Working Group

AU - Ching, Christopher R.K.

AU - Hibar, Derrek P.

AU - Gurholt, Tiril P.

AU - Nunes, Abraham

AU - Thomopoulos, Sophia I.

AU - Abé, Christoph

AU - Agartz, Ingrid

AU - Brouwer, Rachel M.

AU - Cannon, Dara M.

AU - de Zwarte, Sonja M.C.

AU - Eyler, Lisa T.

AU - Favre, Pauline

AU - Hajek, Tomas

AU - Haukvik, Unn K.

AU - Houenou, Josselin

AU - Landén, Mikael

AU - Lett, Tristram A.

AU - McDonald, Colm

AU - Nabulsi, Leila

AU - Patel, Yash

AU - Pauling, Melissa E.

AU - Paus, Tomas

AU - Radua, Joaquim

AU - Soeiro-de-Souza, Marcio G.

AU - Tronchin, Giulia

AU - van Haren, Neeltje E.M.

AU - Vieta, Eduard

AU - Walter, Henrik

AU - Zeng, Ling Li

AU - Alda, Martin

AU - Almeida, Jorge

AU - Alnæs, Dag

AU - Alonso-Lana, Silvia

AU - Altimus, Cara

AU - Bauer, Michael

AU - Baune, Bernhard T.

AU - Bearden, Carrie E.

AU - Bellani, Marcella

AU - Benedetti, Francesco

AU - Berk, Michael

AU - Bilderbeck, Amy C.

AU - Blumberg, Hilary P.

AU - Bøen, Erlend

AU - Bollettini, Irene

AU - del Mar Bonnin, Caterina

AU - Brambilla, Paolo

AU - Canales-Rodríguez, Erick J.

AU - Caseras, Xavier

AU - Dandash, Orwa

AU - Dannlowski, Udo

AU - Delvecchio, Giuseppe

AU - Díaz-Zuluaga, Ana M.

AU - Dima, Danai

AU - Duchesnay, Édouard

AU - Elvsåshagen, Torbjørn

AU - Fears, Scott C.

AU - Frangou, Sophia

AU - Fullerton, Janice M.

AU - Glahn, David C.

AU - Goikolea, Jose M.

AU - Green, Melissa J.

AU - Grotegerd, Dominik

AU - Gruber, Oliver

AU - Haarman, Bartholomeus C.M.

AU - Henry, Chantal

AU - Howells, Fleur M.

AU - Ives-Deliperi, Victoria

AU - Jansen, Andreas

AU - Kircher, Tilo T.J.

AU - Knöchel, Christian

AU - Kramer, Bernd

AU - Lafer, Beny

AU - López-Jaramillo, Carlos

AU - Machado-Vieira, Rodrigo

AU - MacIntosh, Bradley J.

AU - Melloni, Elisa M.T.

AU - Mitchell, Philip B.

AU - Nenadic, Igor

AU - Nery, Fabiano

AU - Nugent, Allison C.

AU - Oertel, Viola

AU - Ophoff, Roel A.

AU - Ota, Miho

AU - Overs, Bronwyn J.

AU - Pham, Daniel L.

AU - Phillips, Mary L.

AU - Pineda-Zapata, Julian A.

AU - Poletti, Sara

AU - Polosan, Mircea

AU - Pomarol-Clotet, Edith

AU - Pouchon, Arnaud

AU - Quidé, Yann

AU - Rive, Maria M.

AU - Roberts, Gloria

AU - Ruhe, Henricus G.

AU - Salvador, Raymond

AU - Sarró, Salvador

AU - Satterthwaite, Theodore D.

AU - Schene, Aart H.

AU - Sim, Kang

AU - Soares, Jair C.

AU - Stäblein, Michael

AU - Stein, Dan J.

AU - Tamnes, Christian K.

AU - Thomaidis, Georgios V.

AU - Upegui, Cristian Vargas

AU - Veltman, Dick J.

AU - Wessa, Michèle

AU - Westlye, Lars T.

AU - Whalley, Heather C.

AU - Wolf, Daniel H.

AU - Wu, Mon Ju

AU - Yatham, Lakshmi N.

AU - Zarate, Carlos A.

AU - Thompson, Paul M.

AU - Andreassen, Ole A.

N1 - Funding Information: O. A. A. received Speaker's honorarium from Lundbeck and is a consultant for HealthLytix. M. B. was supported by an unrestricted grant from AstraZeneca. A. C. B. is a full‐time employee of P1vital Ltd. C. R. K. C. and P. M. T. have received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. T. E. has received a speaker's fee from Lundbeck. G. M. G. is a NIHR Emeritus Senior Investigator, holds shares in P1vital and P1Vital products and has served as consultant, advisor or C. M. E. speaker in the last 3 years for Allergan, Angelini, Compass pathways, MSD, Janssen, Lundbeck (/Otsuka or /Takeda), Medscape, Minerva, P1Vital, Pfizer, Sage, Servier, Shire, Sun Pharma. D. P. H. is a full‐time employee of Genentech, Inc. A. M. M. has received research support from the Eli Lilly, Janssen and The Sackler Trust. J. C. S. has participated in research funded by Forest, Merck, BMS, and GSK and has been a speaker for Pfizer and Abbott. Marsal Sanches has received research grants from Janssen. All other authors from this site report no conflicts of interest to declare. D. J. S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. E. V. has received grants and served as consultant, advisor or CME speaker for the following entities (work unrelated to the topic of this manuscript): AB‐Biotics, Abbott, Allergan, Angelini, Dainippon Sumitomo Pharma, Galenica, Janssen, Lundbeck, Novartis, Otsuka, Sage, Sanofi‐Aventis, and Takeda. Funding Information: The São Paulo (Brazil) studies have been supported by grants from FAPESP‐Brazil (#2009/14891‐9, 2010/18672‐7, 2012/23796‐2 & 2013/03905‐4), CNPq‐Brazil (#478466/2009 & 480370/2009), the Wellcome Trust (UK) and the Brain & Behavior Research Foundation (2010 NARSAD Independent Investigator Award granted to Geraldo F. Busatto). C. A. Z. was supported by Intramural Research Program, National Institute of Mental Health. L.‐L. Z. was supported by National Natural Science Foundation of China (61722313), Fok Ying Tung Education Foundation (161057), and Science & Technology Innovation Program of Hunan Province (2018RS3080). Lastly, we would like to thank all of the ENIGMA Consortium Working Group Members for all their efforts in helping this international consortium effort thrive. Publisher Copyright: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

PY - 2020

Y1 - 2020

N2 - MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.

AB - MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.

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U2 - 10.1002/hbm.25098

DO - 10.1002/hbm.25098

M3 - Review article

C2 - 32725849

AN - SCOPUS:85088655322

SN - 1065-9471

JO - Human Brain Mapping

JF - Human Brain Mapping

ER -

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

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