Alterações topográficas do disco óptico provocadas pela ingestão oral de glicerina

Purpose: To verify the effects on optic disc topography of newly diagnosed glaucoma subjects after ingestion of glycerol, a drug that causes major changes in both the intra-ocular pressure (IOP) and cerebrospinal fluid pressure (CSFP). Methods: We studied 14 patients presenting with intra-ocular pressure over 25 mmHg, without previous use of hypotensive therapy. Results: Glycerol produced a significant intra-ocular pressure average reduction of 28.2% (95% CI of 20.7 to 32.1%). Despite the obtained intraocular pressure reduction, no significant change was observed in any evaluated topographic parameter (cup area and volume, rim area and volume, maximal and mean cup depth). Conclusions: Overall, no significant change in the topographic parameters, using the "Heildelberg Retina Tomograph", was observed after ingestion of glycerol.