An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

Wei Chen; Xiaowei Song; Yunting Zhang; Sultan Darvesh; Ningnannan Zhang; Ryan C.N. D'Arcy; Sandra Black; Kenneth Rockwood

doi:10.1159/000319537

An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

Wei Chen, Xiaowei Song, Yunting Zhang, Sultan Darvesh, Ningnannan Zhang, Ryan C.N. D'Arcy, Sandra Black, Kenneth Rockwood

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

25 Citas (Scopus)

Resumen

Background: This study investigates how T₁-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T₁-and T ₂-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T₁-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

Idioma original	English
Páginas (desde-hasta)	121-130
Número de páginas	10
Publicación	Dementia and Geriatric Cognitive Disorders
Volumen	30
N.º	2
DOI	https://doi.org/10.1159/000319537
Estado	Published - sep. 2010
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging. / Chen, Wei; Song, Xiaowei; Zhang, Yunting et al.
En: Dementia and Geriatric Cognitive Disorders, Vol. 30, N.º 2, 09.2010, p. 121-130.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

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PubMed: MeSH publication types

ODS de las Naciones Unidas

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