An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

Wei Chen; Xiaowei Song; Yunting Zhang; Sultan Darvesh; Ningnannan Zhang; Ryan C.N. D'Arcy; Sandra Black; Kenneth Rockwood

doi:10.1159/000319537

An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

Wei Chen, Xiaowei Song, Yunting Zhang, Sultan Darvesh, Ningnannan Zhang, Ryan C.N. D'Arcy, Sandra Black, Kenneth Rockwood

Résultat de recherche: Article › examen par les pairs

25 Citations (Scopus)

Résumé

Background: This study investigates how T₁-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T₁-and T ₂-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T₁-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

Langue d'origine	English
Pages (de-à)	121-130
Nombre de pages	10
Journal	Dementia and Geriatric Cognitive Disorders
Volume	30
Numéro de publication	2
DOI	https://doi.org/10.1159/000319537
Statut de publication	Published - sept. 2010
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1159/000319537

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abstract = "Background: This study investigates how T1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T1-and T 2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.",

author = "Wei Chen and Xiaowei Song and Yunting Zhang and Sultan Darvesh and Ningnannan Zhang and D'Arcy, {Ryan C.N.} and Sandra Black and Kenneth Rockwood",

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doi = "10.1159/000319537",

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AU - Zhang, Ningnannan

AU - D'Arcy, Ryan C.N.

AU - Black, Sandra

AU - Rockwood, Kenneth

PY - 2010/9

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AB - Background: This study investigates how T1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T1-and T 2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

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An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in alzheimer's disease, mild cognitive impairment and normal aging

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

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