Antimicrobial utilization in very-low-birth-weight infants: association with probiotic use

Canadian Neonatal Network (CNN) Investigators

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Objective: To examine the association between probiotic use and antimicrobial utilization. Study design: We retrospectively evaluated very-low-birth-weight (VLBW) infants admitted to tertiary neonatal intensive care units in Canada between 2014 and 2019. Our outcome was antimicrobial utilization rate (AUR) defined as number of days of antimicrobial exposure per 1000 patient-days. Result: Of 16,223 eligible infants, 7279 (45%) received probiotics. Probiotic use rate increased from 10% in 2014 to 68% in 2019. The AUR was significantly lower in infants who received probiotics vs those who did not (107 vs 129 per 1000 patient-days, aRR = 0.89, 95% CI [0.81, 0.98]). Among 13,305 infants without culture-proven sepsis or necrotizing enterocolitis ≥Stage 2, 5931 (45%) received probiotics. Median AUR was significantly lower in the probiotic vs the no-probiotic group (78 vs 97 per 1000 patient-days, aRR = 0.85, 95% CI [0.74, 0.97]). Conclusion: Probiotic use was associated with a significant reduction in AUR among VLBW infants.

Idioma originalEnglish
PublicaciónJournal of Perinatology
DOI
EstadoAccepted/In press - 2022
Publicado de forma externa

Nota bibliográfica

Funding Information:
Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by the Canadian Institutes of Health Research (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and Mount Sinai Hospital. Dr JYT receives salary support from the Investigator Grant Award Program of the British Columbia Children’s Hospital Research Institute.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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