TY - JOUR
T1 - Antimicrobial utilization in very-low-birth-weight infants
T2 - association with probiotic use
AU - Canadian Neonatal Network (CNN) Investigators
AU - Ting, Joseph Y.
AU - Yoon, Eugene W.
AU - Fajardo, Carlos A.
AU - Daboval, Thierry
AU - Bertelle, Valérie
AU - Shah, Prakesh S.
AU - Shah, Prakesh S.
AU - Beltempo, Marc
AU - Kanungo, Jaideep
AU - Wong, Jonathan
AU - Cieslak, Zenon
AU - Sherlock, Rebecca
AU - Mehrem, Ayman Abou
AU - Toye, Jennifer
AU - Ting, Joseph Y.
AU - Fajardo, Carlos
AU - Bodani, Jaya
AU - Strueby, Lannae
AU - Seshia, Mary
AU - Louis, Deepak
AU - Alvaro, Ruben
AU - Mukerji, Amit
AU - Da Silva, Orlando
AU - Augustine, Sajit
AU - Lee, Kyong Soon
AU - Ng, Eugene
AU - Lemyre, Brigitte
AU - Daboval, Thierry
AU - Khurshid, Faiza
AU - Bizgu, Victoria
AU - Barrington, Keith
AU - Lapointe, Anie
AU - Ethier, Guillaume
AU - Drolet, Christine
AU - Piedboeuf, Bruno
AU - Claveau, Martine
AU - St-Hilaire, Marie
AU - Bertelle, Valerie
AU - Masse, Edith
AU - Canning, Roderick
AU - Makary, Hala
AU - Ojah, Cecil
AU - Monterrosa, Luis
AU - Emberley, Julie
AU - Afifi, Jehier
AU - Kajetanowicz, Andrzej
AU - Lee, Shoo K.
N1 - Funding Information:
Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by the Canadian Institutes of Health Research (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and Mount Sinai Hospital. Dr JYT receives salary support from the Investigator Grant Award Program of the British Columbia Children’s Hospital Research Institute.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - Objective: To examine the association between probiotic use and antimicrobial utilization. Study design: We retrospectively evaluated very-low-birth-weight (VLBW) infants admitted to tertiary neonatal intensive care units in Canada between 2014 and 2019. Our outcome was antimicrobial utilization rate (AUR) defined as number of days of antimicrobial exposure per 1000 patient-days. Result: Of 16,223 eligible infants, 7279 (45%) received probiotics. Probiotic use rate increased from 10% in 2014 to 68% in 2019. The AUR was significantly lower in infants who received probiotics vs those who did not (107 vs 129 per 1000 patient-days, aRR = 0.89, 95% CI [0.81, 0.98]). Among 13,305 infants without culture-proven sepsis or necrotizing enterocolitis ≥Stage 2, 5931 (45%) received probiotics. Median AUR was significantly lower in the probiotic vs the no-probiotic group (78 vs 97 per 1000 patient-days, aRR = 0.85, 95% CI [0.74, 0.97]). Conclusion: Probiotic use was associated with a significant reduction in AUR among VLBW infants.
AB - Objective: To examine the association between probiotic use and antimicrobial utilization. Study design: We retrospectively evaluated very-low-birth-weight (VLBW) infants admitted to tertiary neonatal intensive care units in Canada between 2014 and 2019. Our outcome was antimicrobial utilization rate (AUR) defined as number of days of antimicrobial exposure per 1000 patient-days. Result: Of 16,223 eligible infants, 7279 (45%) received probiotics. Probiotic use rate increased from 10% in 2014 to 68% in 2019. The AUR was significantly lower in infants who received probiotics vs those who did not (107 vs 129 per 1000 patient-days, aRR = 0.89, 95% CI [0.81, 0.98]). Among 13,305 infants without culture-proven sepsis or necrotizing enterocolitis ≥Stage 2, 5931 (45%) received probiotics. Median AUR was significantly lower in the probiotic vs the no-probiotic group (78 vs 97 per 1000 patient-days, aRR = 0.85, 95% CI [0.74, 0.97]). Conclusion: Probiotic use was associated with a significant reduction in AUR among VLBW infants.
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U2 - 10.1038/s41372-022-01382-w
DO - 10.1038/s41372-022-01382-w
M3 - Article
C2 - 35399098
AN - SCOPUS:85130897280
SN - 0743-8346
JO - Journal of Perinatology
JF - Journal of Perinatology
ER -