C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

Ping Yin; Ping Shao; Huikun Liu; Weiqin Li; Leishen Wang; Jing Wang; Shuang Zhang; Junhong Leng; Nan Li; Huiguang Tian; Xilin Yang; Zhijie Yu; Gang Hu

doi:10.1016/j.jdiacomp.2017.08.006

C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

Ping Yin, Ping Shao, Huikun Liu, Weiqin Li, Leishen Wang, Jing Wang, Shuang Zhang, Junhong Leng, Nan Li, Huiguang Tian, Xilin Yang, Zhijie Yu, Gang Hu

Medicine

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4 Citas (Scopus)

Resumen

Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

Idioma original	English
Páginas (desde-hasta)	1658-1662
Número de páginas	5
Publicación	Journal of Diabetes and its Complications
Volumen	31
N.º	12
DOI	https://doi.org/10.1016/j.jdiacomp.2017.08.006
Estado	Published - dic. 2017

Nota bibliográfica

Funding Information:
This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program.

Funding Information:
This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program.

Publisher Copyright:
© 2017 Elsevier Inc.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.jdiacomp.2017.08.006

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@article{f31aaa296224417c82756fa203360ef9,

title = "C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes",

abstract = "Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.",

author = "Ping Yin and Ping Shao and Huikun Liu and Weiqin Li and Leishen Wang and Jing Wang and Shuang Zhang and Junhong Leng and Nan Li and Huiguang Tian and Xilin Yang and Zhijie Yu and Gang Hu",

note = "Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = dec,

doi = "10.1016/j.jdiacomp.2017.08.006",

language = "English",

volume = "31",

pages = "1658--1662",

journal = "Journal of Diabetes and its Complications",

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TY - JOUR

T1 - C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

AU - Yin, Ping

AU - Shao, Ping

AU - Liu, Huikun

AU - Li, Weiqin

AU - Wang, Leishen

AU - Wang, Jing

AU - Zhang, Shuang

AU - Leng, Junhong

AU - Li, Nan

AU - Tian, Huiguang

AU - Yang, Xilin

AU - Yu, Zhijie

AU - Hu, Gang

N1 - Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/12

Y1 - 2017/12

N2 - Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

AB - Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

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C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

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ODS de las Naciones Unidas

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