C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

Ping Yin; Ping Shao; Huikun Liu; Weiqin Li; Leishen Wang; Jing Wang; Shuang Zhang; Junhong Leng; Nan Li; Huiguang Tian; Xilin Yang; Zhijie Yu; Gang Hu

doi:10.1016/j.jdiacomp.2017.08.006

C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

Ping Yin, Ping Shao, Huikun Liu, Weiqin Li, Leishen Wang, Jing Wang, Shuang Zhang, Junhong Leng, Nan Li, Huiguang Tian, Xilin Yang, Zhijie Yu, Gang Hu

Medicine

Résultat de recherche: Article › examen par les pairs

4 Citations (Scopus)

Résumé

Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

Langue d'origine	English
Pages (de-à)	1658-1662
Nombre de pages	5
Journal	Journal of Diabetes and its Complications
Volume	31
Numéro de publication	12
DOI	https://doi.org/10.1016/j.jdiacomp.2017.08.006
Statut de publication	Published - déc. 2017

Note bibliographique

Funding Information:
This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program.

Funding Information:
This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program.

Publisher Copyright:
© 2017 Elsevier Inc.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.jdiacomp.2017.08.006

Autres fichiers et liens

Citer

@article{f31aaa296224417c82756fa203360ef9,

title = "C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes",

abstract = "Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.",

author = "Ping Yin and Ping Shao and Huikun Liu and Weiqin Li and Leishen Wang and Jing Wang and Shuang Zhang and Junhong Leng and Nan Li and Huiguang Tian and Xilin Yang and Zhijie Yu and Gang Hu",

note = "Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = dec,

doi = "10.1016/j.jdiacomp.2017.08.006",

language = "English",

volume = "31",

pages = "1658--1662",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

AU - Yin, Ping

AU - Shao, Ping

AU - Liu, Huikun

AU - Li, Weiqin

AU - Wang, Leishen

AU - Wang, Jing

AU - Zhang, Shuang

AU - Leng, Junhong

AU - Li, Nan

AU - Tian, Huiguang

AU - Yang, Xilin

AU - Yu, Zhijie

AU - Hu, Gang

N1 - Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790 . We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Funding Information: This work was supported by the grant from European Foundation for the Study of Diabetes (EFSD)/Chinese Diabetes Society (CDS)/Lilly programme for Collaborative Research between China and Europe, Tianjin Women's and Children's Health Center, and Tianjin Public Health Bureau. Dr. Hu was supported by grant from National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK100790. We would also like to appreciate all families for participating in the Tianjin Gestational Diabetes Mellitus Prevention Program. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/12

Y1 - 2017/12

N2 - Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

AB - Aims To examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes. Methods A cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1–5 years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes. Results The multivariable-adjusted odds ratios based on different levels of C-peptide (0–33%, 34–66%, 67–90%, and > 90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85–4.39), 2.49 (95% CI 1.06–5.87), and 3.88 (95% CI 1.35–11.1) for diabetes (P for trend < 0.0001), and 1.00, 1.66 (95% CI 1.18–2.36), 2.38 (95% CI 1.56–3.62) and 2.35 (95% CI 1.27–4.37) for pre-diabetes (P for trend < 0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants. Conclusions We found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

UR - http://www.scopus.com/inward/record.url?scp=85029486044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029486044&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2017.08.006

DO - 10.1016/j.jdiacomp.2017.08.006

M3 - Article

C2 - 28919328

AN - SCOPUS:85029486044

SN - 1056-8727

VL - 31

SP - 1658

EP - 1662

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 12

ER -

C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer