Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Ralp E. Mistlberger, Benjamin Rusak

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

Idioma originalEnglish
Páginas (desde-hasta)357-362
Número de páginas6
PublicaciónNeuroscience Letters
Volumen72
N.º3
DOI
EstadoPublished - dic. 23 1986

Nota bibliográfica

Funding Information:
We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.

ASJC Scopus Subject Areas

  • General Neuroscience

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