Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Ralp E. Mistlberger; Benjamin Rusak

doi:10.1016/0304-3940(86)90541-0

Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Ralp E. Mistlberger, Benjamin Rusak

Medicine

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16 Citas (Scopus)

Resumen

Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

Idioma original	English
Páginas (desde-hasta)	357-362
Número de páginas	6
Publicación	Neuroscience Letters
Volumen	72
N.º	3
DOI	https://doi.org/10.1016/0304-3940(86)90541-0
Estado	Published - dic. 23 1986

Nota bibliográfica

Funding Information:
We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.

ASJC Scopus Subject Areas

General Neuroscience

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title = "Carbachol phase shifts circadian activity rhythms in ovariectomized rats",

abstract = "Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.",

author = "Mistlberger, {Ralp E.} and Benjamin Rusak",

note = "Funding Information: We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.",

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doi = "10.1016/0304-3940(86)90541-0",

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T1 - Carbachol phase shifts circadian activity rhythms in ovariectomized rats

AU - Mistlberger, Ralp E.

AU - Rusak, Benjamin

N1 - Funding Information: We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.

PY - 1986/12/23

Y1 - 1986/12/23

N2 - Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

AB - Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

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Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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