Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Ralp E. Mistlberger; Benjamin Rusak

doi:10.1016/0304-3940(86)90541-0

Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Ralp E. Mistlberger, Benjamin Rusak

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

16 Citations (Scopus)

Résumé

Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

Langue d'origine	English
Pages (de-à)	357-362
Nombre de pages	6
Journal	Neuroscience Letters
Volume	72
Numéro de publication	3
DOI	https://doi.org/10.1016/0304-3940(86)90541-0
Statut de publication	Published - déc. 23 1986

Note bibliographique

Funding Information:
We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.

ASJC Scopus Subject Areas

General Neuroscience

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10.1016/0304-3940(86)90541-0

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abstract = "Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.",

author = "Mistlberger, {Ralp E.} and Benjamin Rusak",

note = "Funding Information: We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.",

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doi = "10.1016/0304-3940(86)90541-0",

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T1 - Carbachol phase shifts circadian activity rhythms in ovariectomized rats

AU - Mistlberger, Ralp E.

AU - Rusak, Benjamin

N1 - Funding Information: We thank Donna Goguen and Cathy Legacy-Barrett for technical assistance. This research was supported by an NSERC of Canada Postdoctoral Fellowship (R.E.M.) and by grants from NSERC (A-0305), MRC (MA-8929) and Dalhousie RDFS.

PY - 1986/12/23

Y1 - 1986/12/23

N2 - Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

AB - Ovariectomy in the rat abolishes α-bungarotoxin (α-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically ovariectomized rats before and after intraventricular carbachol injections. Carbachol produced similar phase shifts of the free-running rhythms in all groups. The results suggest that carbachol can influence the circadian system of rats by activation of cholinergic receptor sites independent of those binding α-BTX within the SCN.

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Carbachol phase shifts circadian activity rhythms in ovariectomized rats

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

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