Chemerin: At the crossroads of inflammation and obesity

Matthew C. Ernst; Christopher J. Sinal

doi:10.1016/j.tem.2010.08.001

Chemerin: At the crossroads of inflammation and obesity

Matthew C. Ernst, Christopher J. Sinal

Medicine

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345 Citas (Scopus)

Resumen

Chemerin is a secreted protein with a complex but well-established role in immune function. Parallel lines of investigation also support the notion that chemerin is a novel adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. A growing body of human experimental data indicates that serum chemerin levels are elevated in patients with obesity and that they exhibit a positive correlation with various aspects of the metabolic syndrome. Thus, the dual role of chemerin in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.

Idioma original	English
Páginas (desde-hasta)	660-667
Número de páginas	8
Publicación	Trends in Endocrinology and Metabolism
Volumen	21
N.º	11
DOI	https://doi.org/10.1016/j.tem.2010.08.001
Estado	Published - nov. 2010

Nota bibliográfica

Funding Information:
Figure 1 is based upon an original figure devised and generously provided by Dr Kerry Goralski, Dalhousie University. Research in the Sinal Laboratory is funded by the Canadian Institutes of Health Research. M.E. is the recipient of a studentship award from the Nova Scotia Health Research Foundation.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

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author = "Ernst, {Matthew C.} and Sinal, {Christopher J.}",

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AU - Sinal, Christopher J.

N1 - Funding Information: Figure 1 is based upon an original figure devised and generously provided by Dr Kerry Goralski, Dalhousie University. Research in the Sinal Laboratory is funded by the Canadian Institutes of Health Research. M.E. is the recipient of a studentship award from the Nova Scotia Health Research Foundation.

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N2 - Chemerin is a secreted protein with a complex but well-established role in immune function. Parallel lines of investigation also support the notion that chemerin is a novel adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. A growing body of human experimental data indicates that serum chemerin levels are elevated in patients with obesity and that they exhibit a positive correlation with various aspects of the metabolic syndrome. Thus, the dual role of chemerin in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.

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Chemerin: At the crossroads of inflammation and obesity

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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