Résumé
Chemerin is a secreted protein with a complex but well-established role in immune function. Parallel lines of investigation also support the notion that chemerin is a novel adipokine that regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. A growing body of human experimental data indicates that serum chemerin levels are elevated in patients with obesity and that they exhibit a positive correlation with various aspects of the metabolic syndrome. Thus, the dual role of chemerin in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 660-667 |
| Nombre de pages | 8 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 21 |
| Numéro de publication | 11 |
| DOI | |
| Statut de publication | Published - nov. 2010 |
Note bibliographique
Funding Information:Figure 1 is based upon an original figure devised and generously provided by Dr Kerry Goralski, Dalhousie University. Research in the Sinal Laboratory is funded by the Canadian Institutes of Health Research. M.E. is the recipient of a studentship award from the Nova Scotia Health Research Foundation.
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
