Congenital nephroma of infancy: Induction of renal structures by organ culture

John F.S. Crocker; Robert L. Vernier

doi:10.1016/S0022-3476(72)80455-4

Congenital nephroma of infancy: Induction of renal structures by organ culture

John F.S. Crocker, Robert L. Vernier

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13 Citas (Scopus)

Resumen

A group of renal tumors has been described in newborn infants, which differs from Wilms' tumors by the absence of recognizable renal structures, the presence of sheets of spindle-shaped cells, and the lack of metastasis. Small portions of one of these tumors were placed in organ culture adjacent to fetal mouse brain for 48 to 96 hours. Tumor tissue adjacent to the neural tissue demonstrated palisading of cells within 48 hours and formation of primitive nephron elements within 96 hours. These studies demonstrate that this tumor has a nephrogenic origin and suggest possible investigative approaches to the process of tumor formation through faulty embryonic induction.

Idioma original	English
Páginas (desde-hasta)	69-73
Número de páginas	5
Publicación	Journal of Pediatrics
Volumen	80
N.º	1
DOI	https://doi.org/10.1016/S0022-3476(72)80455-4
Estado	Published - ene. 1972
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
From the University of Minnesota Hospitals, Department of Pediatrics. Supported by the American Heart Association and United States Public Health Service Grant AMHD 15146-01 entitled "Matdevelopment of Embryonic and Fetal Kidney" and HE-06114.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

PubMed: MeSH publication types

Journal Article

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title = "Congenital nephroma of infancy: Induction of renal structures by organ culture",

abstract = "A group of renal tumors has been described in newborn infants, which differs from Wilms' tumors by the absence of recognizable renal structures, the presence of sheets of spindle-shaped cells, and the lack of metastasis. Small portions of one of these tumors were placed in organ culture adjacent to fetal mouse brain for 48 to 96 hours. Tumor tissue adjacent to the neural tissue demonstrated palisading of cells within 48 hours and formation of primitive nephron elements within 96 hours. These studies demonstrate that this tumor has a nephrogenic origin and suggest possible investigative approaches to the process of tumor formation through faulty embryonic induction.",

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note = "Funding Information: From the University of Minnesota Hospitals, Department of Pediatrics. Supported by the American Heart Association and United States Public Health Service Grant AMHD 15146-01 entitled {"}Matdevelopment of Embryonic and Fetal Kidney{"} and HE-06114.",

year = "1972",

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AU - Vernier, Robert L.

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PY - 1972/1

Y1 - 1972/1

N2 - A group of renal tumors has been described in newborn infants, which differs from Wilms' tumors by the absence of recognizable renal structures, the presence of sheets of spindle-shaped cells, and the lack of metastasis. Small portions of one of these tumors were placed in organ culture adjacent to fetal mouse brain for 48 to 96 hours. Tumor tissue adjacent to the neural tissue demonstrated palisading of cells within 48 hours and formation of primitive nephron elements within 96 hours. These studies demonstrate that this tumor has a nephrogenic origin and suggest possible investigative approaches to the process of tumor formation through faulty embryonic induction.

AB - A group of renal tumors has been described in newborn infants, which differs from Wilms' tumors by the absence of recognizable renal structures, the presence of sheets of spindle-shaped cells, and the lack of metastasis. Small portions of one of these tumors were placed in organ culture adjacent to fetal mouse brain for 48 to 96 hours. Tumor tissue adjacent to the neural tissue demonstrated palisading of cells within 48 hours and formation of primitive nephron elements within 96 hours. These studies demonstrate that this tumor has a nephrogenic origin and suggest possible investigative approaches to the process of tumor formation through faulty embryonic induction.

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Congenital nephroma of infancy: Induction of renal structures by organ culture

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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