Pisanu, C., Congiu, D., Manchia, M., Caria, P., Cocco, C., Dettori, T., Frau, D. V., Manca, E., Meloni, A., Nieddu, M., Noli, B., Pinna, F., Robledo, R., Sogos, V., Ferri, G. L., Carpiniello, B., Vanni, R., Bocchetta, A., Severino, G., ... Squassina, A. (2020). Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment. Pharmacogenomics, 21(8), 533-540. https://doi.org/10.2217/pgs-2020-0028
Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment. / Pisanu, Claudia; Congiu, Donatella
; Manchia, Mirko et al.
En:
Pharmacogenomics, Vol. 21, N.º 8, 06.2020, p. 533-540.
Producción científica: Contribución a una revista › Artículo › revisión exhaustiva
Pisanu, C, Congiu, D, Manchia, M, Caria, P, Cocco, C, Dettori, T, Frau, DV, Manca, E, Meloni, A, Nieddu, M, Noli, B, Pinna, F, Robledo, R, Sogos, V, Ferri, GL, Carpiniello, B, Vanni, R, Bocchetta, A, Severino, G, Ardau, R, Chillotti, C, Zompo, MD & Squassina, A 2020, 'Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment', Pharmacogenomics, vol. 21, n.º 8, pp. 533-540. https://doi.org/10.2217/pgs-2020-0028
Pisanu C, Congiu D, Manchia M, Caria P, Cocco C, Dettori T et al. Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment. Pharmacogenomics. 2020 jun.;21(8):533-540. doi: 10.2217/pgs-2020-0028
Pisanu, Claudia ; Congiu, Donatella ; Manchia, Mirko et al. / Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment. En: Pharmacogenomics. 2020 ; Vol. 21, N.º 8. pp. 533-540.
@article{ce2c21571724473caf7bee87ce37fd5e,
title = "Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment",
abstract = "Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.",
author = "Claudia Pisanu and Donatella Congiu and Mirko Manchia and Paola Caria and Cristina Cocco and Tinuccia Dettori and Frau, {Daniela Virginia} and Elias Manca and Anna Meloni and Mariella Nieddu and Barbara Noli and Federica Pinna and Renato Robledo and Valeria Sogos and Ferri, {Gian Luca} and Bernardo Carpiniello and Roberta Vanni and Alberto Bocchetta and Giovanni Severino and Raffaella Ardau and Caterina Chillotti and Zompo, {Maria Del} and Alessio Squassina",
note = "Funding Information: This study was funded by the Fondazione di Sardegna and Regione Sardegna, call 2016, project ID: F72F16003090002. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.",
year = "2020",
month = jun,
doi = "10.2217/pgs-2020-0028",
language = "English",
volume = "21",
pages = "533--540",
journal = "Pharmacogenomics",
issn = "1462-2416",
publisher = "Future Medicine Ltd.",
number = "8",
}
TY - JOUR
T1 - Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment
AU - Pisanu, Claudia
AU - Congiu, Donatella
AU - Manchia, Mirko
AU - Caria, Paola
AU - Cocco, Cristina
AU - Dettori, Tinuccia
AU - Frau, Daniela Virginia
AU - Manca, Elias
AU - Meloni, Anna
AU - Nieddu, Mariella
AU - Noli, Barbara
AU - Pinna, Federica
AU - Robledo, Renato
AU - Sogos, Valeria
AU - Ferri, Gian Luca
AU - Carpiniello, Bernardo
AU - Vanni, Roberta
AU - Bocchetta, Alberto
AU - Severino, Giovanni
AU - Ardau, Raffaella
AU - Chillotti, Caterina
AU - Zompo, Maria Del
AU - Squassina, Alessio
N1 - Funding Information:
This study was funded by the Fondazione di Sardegna and Regione Sardegna, call 2016, project ID: F72F16003090002. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2020 Future Medicine Ltd.
PY - 2020/6
Y1 - 2020/6
N2 - Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.
AB - Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.
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U2 - 10.2217/pgs-2020-0028
DO - 10.2217/pgs-2020-0028
M3 - Article
C2 - 32372689
AN - SCOPUS:85086682149
SN - 1462-2416
VL - 21
SP - 533
EP - 540
JO - Pharmacogenomics
JF - Pharmacogenomics
IS - 8
ER -