Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

Claudia Pisanu; Donatella Congiu; Mirko Manchia; Paola Caria; Cristina Cocco; Tinuccia Dettori; Daniela Virginia Frau; Elias Manca; Anna Meloni; Mariella Nieddu; Barbara Noli; Federica Pinna; Renato Robledo; Valeria Sogos; Gian Luca Ferri; Bernardo Carpiniello; Roberta Vanni; Alberto Bocchetta; Giovanni Severino; Raffaella Ardau; Caterina Chillotti; Maria Del Zompo; Alessio Squassina

doi:10.2217/pgs-2020-0028

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

Claudia Pisanu, Donatella Congiu, Mirko Manchia, Paola Caria, Cristina Cocco, Tinuccia Dettori, Daniela Virginia Frau, Elias Manca, Anna Meloni, Mariella Nieddu, Barbara Noli, Federica Pinna, Renato Robledo, Valeria Sogos, Gian Luca Ferri, Bernardo Carpiniello, Roberta Vanni, Alberto Bocchetta, Giovanni Severino, Raffaella ArdauCaterina Chillotti, Maria Del Zompo, Alessio Squassina

Medicine

Résultat de recherche: Article › examen par les pairs

30 Citations (Scopus)

Résumé

Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.

Langue d'origine	English
Pages (de-à)	533-540
Nombre de pages	8
Journal	Pharmacogenomics
Volume	21
Numéro de publication	8
DOI	https://doi.org/10.2217/pgs-2020-0028
Statut de publication	Published - juin 2020

Note bibliographique

Funding Information:
This study was funded by the Fondazione di Sardegna and Regione Sardegna, call 2016, project ID: F72F16003090002. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2020 Future Medicine Ltd.

ASJC Scopus Subject Areas

Molecular Medicine
Genetics
Pharmacology

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10.2217/pgs-2020-0028

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Pisanu, C., Congiu, D., Manchia, M., Caria, P., Cocco, C., Dettori, T., Frau, D. V., Manca, E., Meloni, A., Nieddu, M., Noli, B., Pinna, F., Robledo, R., Sogos, V., Ferri, G. L., Carpiniello, B., Vanni, R., Bocchetta, A., Severino, G., ... Squassina, A. (2020). Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment. Pharmacogenomics, 21(8), 533-540. https://doi.org/10.2217/pgs-2020-0028

Pisanu, C, Congiu, D, Manchia, M, Caria, P, Cocco, C, Dettori, T, Frau, DV, Manca, E, Meloni, A, Nieddu, M, Noli, B, Pinna, F, Robledo, R, Sogos, V, Ferri, GL, Carpiniello, B, Vanni, R, Bocchetta, A, Severino, G, Ardau, R, Chillotti, C, Zompo, MD & Squassina, A 2020, 'Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment', Pharmacogenomics, vol. 21, n° 8, pp. 533-540. https://doi.org/10.2217/pgs-2020-0028

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title = "Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment",

abstract = "Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.",

author = "Claudia Pisanu and Donatella Congiu and Mirko Manchia and Paola Caria and Cristina Cocco and Tinuccia Dettori and Frau, {Daniela Virginia} and Elias Manca and Anna Meloni and Mariella Nieddu and Barbara Noli and Federica Pinna and Renato Robledo and Valeria Sogos and Ferri, {Gian Luca} and Bernardo Carpiniello and Roberta Vanni and Alberto Bocchetta and Giovanni Severino and Raffaella Ardau and Caterina Chillotti and Zompo, {Maria Del} and Alessio Squassina",

note = "Funding Information: This study was funded by the Fondazione di Sardegna and Regione Sardegna, call 2016, project ID: F72F16003090002. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.",

year = "2020",

month = jun,

doi = "10.2217/pgs-2020-0028",

language = "English",

volume = "21",

pages = "533--540",

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T1 - Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

AU - Pisanu, Claudia

AU - Congiu, Donatella

AU - Manchia, Mirko

AU - Caria, Paola

AU - Cocco, Cristina

AU - Dettori, Tinuccia

AU - Frau, Daniela Virginia

AU - Manca, Elias

AU - Meloni, Anna

AU - Nieddu, Mariella

AU - Noli, Barbara

AU - Pinna, Federica

AU - Robledo, Renato

AU - Sogos, Valeria

AU - Ferri, Gian Luca

AU - Carpiniello, Bernardo

AU - Vanni, Roberta

AU - Bocchetta, Alberto

AU - Severino, Giovanni

AU - Ardau, Raffaella

AU - Chillotti, Caterina

AU - Zompo, Maria Del

AU - Squassina, Alessio

N1 - Funding Information: This study was funded by the Fondazione di Sardegna and Regione Sardegna, call 2016, project ID: F72F16003090002. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2020 Future Medicine Ltd.

PY - 2020/6

Y1 - 2020/6

N2 - Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.

AB - Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets. Results: Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL. Conclusion: Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.

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Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment

Résumé

Note bibliographique

ASJC Scopus Subject Areas

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