Epidemiology of post-hemorrhagic ventricular dilatation in very preterm infants

Canadian Neonatal Network Investigators

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

4 Citas (Scopus)

Resumen

Objective: To describe the incidence, trends, management’s variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD). Methods: We reviewed infants <33 weeks’ gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt. Results: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD. Conclusions: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.

Idioma originalEnglish
PublicaciónJournal of Perinatology
DOI
EstadoAccepted/In press - 2022
Publicado de forma externa

Nota bibliográfica

Funding Information:
The project described in this manuscript was conducted with no specific financial support. No honorarium, grant, or other form of payment was given to anyone to produce this manuscript. Organizational support for the Canadian Neonatal Network™ was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by the Canadian Institutes of Health Research (CIHR) (CTP 87518) and Mount Sinai Hospital. PS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

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