TY - JOUR
T1 - Epidemiology of post-hemorrhagic ventricular dilatation in very preterm infants
AU - Canadian Neonatal Network Investigators
AU - Afifi, Jehier
AU - Shah, Prakesh S.
AU - Ye, Xiang Y.
AU - Shah, Vibhuti
AU - Piedboeuf, Bruno
AU - Barrington, Keith
AU - Kelly, Edmond
AU - El-Naggar, Walid
AU - Shah, Prakesh
AU - Beltempo, Marc
AU - Kanungo, Jaideep
AU - Wong, Jonathan
AU - Cieslak, Zenon
AU - Sherlock, Rebecca
AU - Mehrem, Ayman Abou
AU - Toye, Jennifer
AU - Aziz, Khalid
AU - Ting, Joseph
AU - Fajarado, Carlos
AU - Bodani, Jaya
AU - Strueby, Lannae
AU - Seshia, Mary
AU - Louis, Deepak
AU - Alvaro, Ruben
AU - Mukerji, Amit
AU - Da Silva, Orlando
AU - Augustine, Sajit
AU - Lee, Kyong Soon
AU - Ng, Eugene
AU - Lemyre, Brigitte
AU - Daboval, Thierry
AU - Khurshid, Faiza
AU - Bizgu, Victoria
AU - Lapointe, Anie
AU - Ethier, Guillaume
AU - Drolet, Christine
AU - Claveau, Martine
AU - St-Hilaire, Marie
AU - Bertelle, Valerie
AU - Masse, Edith
AU - Canning, Roderick
AU - Makary, Hala
AU - Ojah, Cecil
AU - Emberley, Julie
AU - Kajetanowicz, Andrzej
AU - Lee, Shoo K.
N1 - Funding Information:
The project described in this manuscript was conducted with no specific financial support. No honorarium, grant, or other form of payment was given to anyone to produce this manuscript. Organizational support for the Canadian Neonatal Network™ was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by the Canadian Institutes of Health Research (CIHR) (CTP 87518) and Mount Sinai Hospital. PS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340).
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - Objective: To describe the incidence, trends, management’s variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD). Methods: We reviewed infants <33 weeks’ gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt. Results: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD. Conclusions: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.
AB - Objective: To describe the incidence, trends, management’s variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD). Methods: We reviewed infants <33 weeks’ gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt. Results: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD. Conclusions: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.
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U2 - 10.1038/s41372-022-01483-6
DO - 10.1038/s41372-022-01483-6
M3 - Article
C2 - 35945347
AN - SCOPUS:85135779032
SN - 0743-8346
JO - Journal of Perinatology
JF - Journal of Perinatology
ER -