Falsely raised plasma theophylline concentrations in renal failure

A. A. Nanji; D. C. Greenway

doi:10.1007/BF00540962

Falsely raised plasma theophylline concentrations in renal failure

A. A. Nanji, D. C. Greenway

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.

Idioma original	English
Páginas (desde-hasta)	309-310
Número de páginas	2
Publicación	European Journal of Clinical Pharmacology
Volumen	34
N.º	3
DOI	https://doi.org/10.1007/BF00540962
Estado	Published - abr. 1988
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)

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abstract = "We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.",

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AU - Greenway, D. C.

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AB - We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.

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Falsely raised plasma theophylline concentrations in renal failure

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