Falsely raised plasma theophylline concentrations in renal failure

A. A. Nanji; D. C. Greenway

doi:10.1007/BF00540962

Falsely raised plasma theophylline concentrations in renal failure

A. A. Nanji, D. C. Greenway

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Résumé

We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.

Langue d'origine	English
Pages (de-à)	309-310
Nombre de pages	2
Journal	European Journal of Clinical Pharmacology
Volume	34
Numéro de publication	3
DOI	https://doi.org/10.1007/BF00540962
Statut de publication	Published - avr. 1988
Publié à l'externe	Oui

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)

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10.1007/BF00540962

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title = "Falsely raised plasma theophylline concentrations in renal failure",

abstract = "We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.",

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AU - Nanji, A. A.

AU - Greenway, D. C.

PY - 1988/4

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AB - We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean±SD (μmol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4±36.7; EIA 64.4±35.9; FPIA 70±3.43; DI 122±65.9. A significant correlation (r=0.94, p<0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.

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Falsely raised plasma theophylline concentrations in renal failure

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