Guggulsterone: An old approach to a new problem

Christopher J. Sinal; Frank J. Gonzalez

doi:10.1016/S1043-2760(02)00640-9

Guggulsterone: An old approach to a new problem

Christopher J. Sinal, Frank J. Gonzalez

Medicine

Medicine

Producción científica: Contribución a una revista › Encuesta corta › revisión exhaustiva

70 Citas (Scopus)

Resumen

The hepatic conversion of cholesterol to bile acids is an important mechanism for the elimination of excess dietary cholesterol. Bile acid biosynthesis and transport are regulated by the farnesoid X receptor (FXR), a member of the of nuclear hormone receptor gene superfamily. Thus, therapeutic strategies that target FXR represent a promising new approach for the treatment of hypercholesterolemia. Recent studies have provided new evidence in support of the potential for FXR ligands as antihypercholesterolemic agents.

Idioma original	English
Páginas (desde-hasta)	275-276
Número de páginas	2
Publicación	Trends in Endocrinology and Metabolism
Volumen	13
N.º	7
DOI	https://doi.org/10.1016/S1043-2760(02)00640-9
Estado	Published - sep. 2002

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

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Guggulsterone: An old approach to a new problem

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