Guggulsterone: An old approach to a new problem

Christopher J. Sinal; Frank J. Gonzalez

doi:10.1016/S1043-2760(02)00640-9

Guggulsterone: An old approach to a new problem

Christopher J. Sinal, Frank J. Gonzalez

Medicine

Medicine

Résultat de recherche: Short survey › examen par les pairs

70 Citations (Scopus)

Résumé

The hepatic conversion of cholesterol to bile acids is an important mechanism for the elimination of excess dietary cholesterol. Bile acid biosynthesis and transport are regulated by the farnesoid X receptor (FXR), a member of the of nuclear hormone receptor gene superfamily. Thus, therapeutic strategies that target FXR represent a promising new approach for the treatment of hypercholesterolemia. Recent studies have provided new evidence in support of the potential for FXR ligands as antihypercholesterolemic agents.

Langue d'origine	English
Pages (de-à)	275-276
Nombre de pages	2
Journal	Trends in Endocrinology and Metabolism
Volume	13
Numéro de publication	7
DOI	https://doi.org/10.1016/S1043-2760(02)00640-9
Statut de publication	Published - sept. 2002

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

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10.1016/S1043-2760(02)00640-9

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abstract = "The hepatic conversion of cholesterol to bile acids is an important mechanism for the elimination of excess dietary cholesterol. Bile acid biosynthesis and transport are regulated by the farnesoid X receptor (FXR), a member of the of nuclear hormone receptor gene superfamily. Thus, therapeutic strategies that target FXR represent a promising new approach for the treatment of hypercholesterolemia. Recent studies have provided new evidence in support of the potential for FXR ligands as antihypercholesterolemic agents.",

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Guggulsterone: An old approach to a new problem

Résumé

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

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