How CCT puts a leash on phospholipid synthesis

Neale D. Ridgway

doi:10.1074/jbc.H118.002882

How CCT puts a leash on phospholipid synthesis

Neale D. Ridgway

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

1 Cita (Scopus)

Resumen

The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase (CCT), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. However, the detailed mechanism by which this domain regulates CCT activity is not clear. Ramezanpour et al. use a combined computational and biochemical approach to define new details of this mechanism, providing an elegant illustration of how the lipid-sensing domain of a phospholipid biosynthetic enzyme controls membrane homeostasis.

Idioma original	English
Páginas (desde-hasta)	7085-7086
Número de páginas	2
Publicación	Journal of Biological Chemistry
Volumen	293
N.º	18
DOI	https://doi.org/10.1074/jbc.H118.002882
Estado	Published - may. 4 2018

Nota bibliográfica

Funding Information:
This work was supported by Institute of Nutrition, Metabolism, and Diabetes (INMD), Canadian Institutes of Health Research Grant 136809. The author declares that he has no conflicts of interest with the contents of the article.

Publisher Copyright:
© 2018 Ridgway Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
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N1 - Funding Information: This work was supported by Institute of Nutrition, Metabolism, and Diabetes (INMD), Canadian Institutes of Health Research Grant 136809. The author declares that he has no conflicts of interest with the contents of the article. Publisher Copyright: © 2018 Ridgway Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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N2 - The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase (CCT), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. However, the detailed mechanism by which this domain regulates CCT activity is not clear. Ramezanpour et al. use a combined computational and biochemical approach to define new details of this mechanism, providing an elegant illustration of how the lipid-sensing domain of a phospholipid biosynthetic enzyme controls membrane homeostasis.

AB - The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase (CCT), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. However, the detailed mechanism by which this domain regulates CCT activity is not clear. Ramezanpour et al. use a combined computational and biochemical approach to define new details of this mechanism, providing an elegant illustration of how the lipid-sensing domain of a phospholipid biosynthetic enzyme controls membrane homeostasis.

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How CCT puts a leash on phospholipid synthesis

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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