Résumé
The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase (CCT), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. However, the detailed mechanism by which this domain regulates CCT activity is not clear. Ramezanpour et al. use a combined computational and biochemical approach to define new details of this mechanism, providing an elegant illustration of how the lipid-sensing domain of a phospholipid biosynthetic enzyme controls membrane homeostasis.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 7085-7086 |
| Nombre de pages | 2 |
| Journal | Journal of Biological Chemistry |
| Volume | 293 |
| Numéro de publication | 18 |
| DOI | |
| Statut de publication | Published - mai 4 2018 |
Note bibliographique
Funding Information:This work was supported by Institute of Nutrition, Metabolism, and Diabetes (INMD), Canadian Institutes of Health Research Grant 136809. The author declares that he has no conflicts of interest with the contents of the article.
Publisher Copyright:
© 2018 Ridgway Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
ASJC Scopus Subject Areas
- Biochemistry
- Molecular Biology
- Cell Biology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
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