Multiple facets of TRPML1 in autophagy

Peng Huang; Mengnan Xu; Yi Wu; Alia Kazim Rizvi Syeda; Xian Ping Dong

doi:10.1016/j.ceca.2020.102196

Multiple facets of TRPML1 in autophagy

Peng Huang, Mengnan Xu, Yi Wu, Alia Kazim Rizvi Syeda, Xian Ping Dong

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

16 Citas (Scopus)

Resumen

Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.

Idioma original	English
Número de artículo	102196
Publicación	Cell Calcium
Volumen	88
DOI	https://doi.org/10.1016/j.ceca.2020.102196
Estado	Published - jun. 2020

Nota bibliográfica

Funding Information:
This work was supported by Canadian Institutes of Health Research (CIHR), Canada , grant number PJT-156102 .

Publisher Copyright:
© 2020 Elsevier Ltd

ASJC Scopus Subject Areas

Physiology
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article

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title = "Multiple facets of TRPML1 in autophagy",

abstract = "Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.",

author = "Peng Huang and Mengnan Xu and Yi Wu and {Rizvi Syeda}, {Alia Kazim} and Dong, {Xian Ping}",

note = "Funding Information: This work was supported by Canadian Institutes of Health Research (CIHR), Canada , grant number PJT-156102 . Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

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AU - Xu, Mengnan

AU - Wu, Yi

AU - Rizvi Syeda, Alia Kazim

AU - Dong, Xian Ping

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Multiple facets of TRPML1 in autophagy

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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