Multiple facets of TRPML1 in autophagy

Peng Huang; Mengnan Xu; Yi Wu; Alia Kazim Rizvi Syeda; Xian Ping Dong

doi:10.1016/j.ceca.2020.102196

Multiple facets of TRPML1 in autophagy

Peng Huang, Mengnan Xu, Yi Wu, Alia Kazim Rizvi Syeda, Xian Ping Dong

Résultat de recherche: Article › examen par les pairs

16 Citations (Scopus)

Résumé

Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.

Langue d'origine	English
Numéro d'article	102196
Journal	Cell Calcium
Volume	88
DOI	https://doi.org/10.1016/j.ceca.2020.102196
Statut de publication	Published - juin 2020

Note bibliographique

Funding Information:
This work was supported by Canadian Institutes of Health Research (CIHR), Canada , grant number PJT-156102 .

Publisher Copyright:
© 2020 Elsevier Ltd

ASJC Scopus Subject Areas

Physiology
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.ceca.2020.102196

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title = "Multiple facets of TRPML1 in autophagy",

abstract = "Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.",

author = "Peng Huang and Mengnan Xu and Yi Wu and {Rizvi Syeda}, {Alia Kazim} and Dong, {Xian Ping}",

note = "Funding Information: This work was supported by Canadian Institutes of Health Research (CIHR), Canada , grant number PJT-156102 . Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

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doi = "10.1016/j.ceca.2020.102196",

language = "English",

volume = "88",

journal = "Cell Calcium",

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AU - Huang, Peng

AU - Xu, Mengnan

AU - Wu, Yi

AU - Rizvi Syeda, Alia Kazim

AU - Dong, Xian Ping

PY - 2020/6

Y1 - 2020/6

N2 - Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.

AB - Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.

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Multiple facets of TRPML1 in autophagy

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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