Novel jadomycins: Incorporation of non-natural and natural amino acids

David L. Jakeman; Spring Farrell; Wendy Young; René J. Doucet; Shannon C. Timmons

doi:10.1016/j.bmcl.2004.12.082

Novel jadomycins: Incorporation of non-natural and natural amino acids

David L. Jakeman, Spring Farrell, Wendy Young, René J. Doucet, Shannon C. Timmons

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

40 Citas (Scopus)

Resumen

Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.

Idioma original	English
Páginas (desde-hasta)	1447-1449
Número de páginas	3
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	15
N.º	5
DOI	https://doi.org/10.1016/j.bmcl.2004.12.082
Estado	Published - mar. 1 2005

Nota bibliográfica

Funding Information:
We thank the Atlantic Chapter of the Canadian Breast Cancer Foundation, the Canada Foundation for Innovation and the Nova Scotia Innovation Trust for funding, and L. C. Vining and E. Rowland for helpful discussions.

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

PubMed: MeSH publication types

Journal Article

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10.1016/j.bmcl.2004.12.082

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abstract = "Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.",

author = "Jakeman, {David L.} and Spring Farrell and Wendy Young and Doucet, {Ren{\'e} J.} and Timmons, {Shannon C.}",

note = "Funding Information: We thank the Atlantic Chapter of the Canadian Breast Cancer Foundation, the Canada Foundation for Innovation and the Nova Scotia Innovation Trust for funding, and L. C. Vining and E. Rowland for helpful discussions. ",

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AU - Young, Wendy

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AU - Timmons, Shannon C.

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Novel jadomycins: Incorporation of non-natural and natural amino acids

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

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