Novel jadomycins: Incorporation of non-natural and natural amino acids

David L. Jakeman; Spring Farrell; Wendy Young; René J. Doucet; Shannon C. Timmons

doi:10.1016/j.bmcl.2004.12.082

Novel jadomycins: Incorporation of non-natural and natural amino acids

David L. Jakeman, Spring Farrell, Wendy Young, René J. Doucet, Shannon C. Timmons

Medicine

Résultat de recherche: Article › examen par les pairs

40 Citations (Scopus)

Résumé

Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.

Langue d'origine	English
Pages (de-à)	1447-1449
Nombre de pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Numéro de publication	5
DOI	https://doi.org/10.1016/j.bmcl.2004.12.082
Statut de publication	Published - mars 1 2005

Note bibliographique

Funding Information:
We thank the Atlantic Chapter of the Canadian Breast Cancer Foundation, the Canada Foundation for Innovation and the Nova Scotia Innovation Trust for funding, and L. C. Vining and E. Rowland for helpful discussions.

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

PubMed: MeSH publication types

Journal Article

Accès au document

10.1016/j.bmcl.2004.12.082

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abstract = "Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural l-amino acids, d-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.",

author = "Jakeman, {David L.} and Spring Farrell and Wendy Young and Doucet, {Ren{\'e} J.} and Timmons, {Shannon C.}",

note = "Funding Information: We thank the Atlantic Chapter of the Canadian Breast Cancer Foundation, the Canada Foundation for Innovation and the Nova Scotia Innovation Trust for funding, and L. C. Vining and E. Rowland for helpful discussions. ",

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AU - Timmons, Shannon C.

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Novel jadomycins: Incorporation of non-natural and natural amino acids

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

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