Prediction of the functional refractory period of the atrioventricular node

Peter E. Dresel; Ricky Y.K. Man

doi:10.1016/S0022-0736(78)80101-0

Prediction of the functional refractory period of the atrioventricular node

Peter E. Dresel, Ricky Y.K. Man

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

2 Citas (Scopus)

Resumen

Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.

Idioma original	English
Páginas (desde-hasta)	123-127
Número de páginas	5
Publicación	Journal of Electrocardiology
Volumen	11
N.º	2
DOI	https://doi.org/10.1016/S0022-0736(78)80101-0
Estado	Published - 1978

Nota bibliográfica

Funding Information:
The concept of the functional refractory period of atrioventricular transmission was developed by Krayer et al, 1 who studied the effect of epinephrine and veratramine on the transmission of impulses between atria and ventricles. It has been commonly employed to determine the effect of physiological, pharmacological and pathological factors on atrioventricular conduction. It is defined as the minimum interval between ventricular activations which are conducted from the versity, Halifax, Nova Scotia, Canada, and the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Aided by grants from the Medical Research Council of Canada and the Manitoba Heart Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. w1 734 solely to indicate this fact. *Graduate Fellow, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, P.Q., Canada. Reprint requests to: Peter E. Dresel, Ph.D., Professor and Head, Department of Pharmacology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

Journal Article

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title = "Prediction of the functional refractory period of the atrioventricular node",

abstract = "Based on the new description of AV-nodal conductivity from our laboratory, we developed an equation which describes AV-nodal conduction time in the dog heart at all coupling intervals. This allows us to predict the functional refractory period (FRP) of the AV-node based on the AV-nodal conduction times of only five extra stimuli having relatively long coupling intervals. The equation predicted the FRP within acceptable limits when compared to values obtained by the classical technique in which the full range of extrasystolic intervals must be tested. Changes in FRP after the administration of antirrrhythmic drugs (lidocaine and quinidine) or due to changes in heart rate were predicted accurately. The ease and accuracy of the present method could allow determination of FRP in a short time.",

author = "Dresel, {Peter E.} and Man, {Ricky Y.K.}",

note = "Funding Information: The concept of the functional refractory period of atrioventricular transmission was developed by Krayer et al, 1 who studied the effect of epinephrine and veratramine on the transmission of impulses between atria and ventricles. It has been commonly employed to determine the effect of physiological, pharmacological and pathological factors on atrioventricular conduction. It is defined as the minimum interval between ventricular activations which are conducted from the versity, Halifax, Nova Scotia, Canada, and the Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Aided by grants from the Medical Research Council of Canada and the Manitoba Heart Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked {"}advertisement{"} in accordance with 18 U.S.C. w1 734 solely to indicate this fact. *Graduate Fellow, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, P.Q., Canada. Reprint requests to: Peter E. Dresel, Ph.D., Professor and Head, Department of Pharmacology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7.",

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Prediction of the functional refractory period of the atrioventricular node

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ASJC Scopus Subject Areas

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